Association between inflammatory bowel disease and Parkinson's disease: a prospective cohort study of 468,556 UK biobank participants

Hai-Li Wang; Zhi-Yun Wang; Jie Tian; Dong-Rui Ma; Chang-He Shi

doi:10.3389/fnagi.2023.1294879

Association between inflammatory bowel disease and Parkinson's disease: a prospective cohort study of 468,556 UK biobank participants

Front Aging Neurosci. 2024 Jan 15:15:1294879. doi: 10.3389/fnagi.2023.1294879. eCollection 2023.

Authors

Hai-Li Wang^#¹, Zhi-Yun Wang^#², Jie Tian^#³, Dong-Rui Ma², Chang-He Shi²

Affiliations

¹ Department of Surgery ICU, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China.
² Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China.
³ Zhengzhou Railway Vocational and Technical College, Zhengzhou, Henan, China.

^# Contributed equally.

Abstract

Introduction: Inflammatory Bowel Disease (IBD) and Parkinson's disease (PD) are both chronic, progressive disorders. As such, given the inconclusive results of extensive research on the association between IBD and PD, our study intends to examine this relationship further using the UK Biobank database.

Methods: We conducted a prospective cohort study using the Cox proportional hazards model, analyzing data from the UK Biobank to investigate the relationship between IBD and PD, following subjects until PD diagnosis, loss to follow up, death or study termination on 30 June, 2023.

Results: The results show that IBD had no effect on the risk of PD (HR: 1.356, 95% CI: 0.941-1.955, p = 0.103), and the effect remained consistent in specific Crohn's disease, ulcerative colitis or unclassified IBD populations. In addition, after sensitivity analysis using propensity matching scores and excluding patients diagnosed with PD 5 or 10 years after baseline, IBD had no effect on the risk of PD. However, in the subgroup analysis, we found that in females (HR: 1.989, 95% CI: 1.032-3.835, p = 0.040), the polygenic risk score was highest (HR: 2.476, 95% CI: 1.401-4.374, p = 0.002), and having ulcerative colitis without hypertension (HR: 2.042, 95% CI: 1.128-3.697, p = 0.018) was associated with an increased risk of PD.

Conclusion: In conclusion, over an average follow-up period of 13.93 years, we found no significant association between IBD and PD.

Keywords: Parkinson’s disease; inflammatory bowel disease; polygenic risk score; propensity score matching; prospective cohort study.

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the National Natural Science Foundation of China to C-hS [grant numbers 82171247 and 82371433], the Scientific Research and Innovation Team of the First Affiliated Hospital of Zhengzhou University to C-hS [grant number ZYCXTD2023011], the Scientific and Technological Research Projects in Henan Province to JT [grant number 222102310033], and the Key Research Project in Higher Education Institutions of Henan Province to JT [grant number 22B320022].