Case report: A case of Acute Macular Neuroretinopathy secondary to Influenza A virus during Long COVID

Jiaqi Zhang; Yihao Xia; Xiaodong Li; Runxi He; Xuejun Xie

doi:10.3389/fimmu.2023.1302504

Case report: A case of Acute Macular Neuroretinopathy secondary to Influenza A virus during Long COVID

Front Immunol. 2024 Jan 15:14:1302504. doi: 10.3389/fimmu.2023.1302504. eCollection 2023.

Authors

Jiaqi Zhang^{1

2}, Yihao Xia^{1

2}, Xiaodong Li³, Runxi He^{1

2}, Xuejun Xie⁴

Affiliations

¹ Chengdu University of Traditional Chinese Medicine, Chengdu, China.
² Eye School of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
³ The First Affiliated Hospital, Guizhou University of Traditional Chinese Medicine, Guiyang, China.
⁴ Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Abstract

Ocular abnormalities have been reported in association with viral infections, including Long COVID, a debilitating illness caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). This report presents a case of a female patient diagnosed with Acute Macular Neuroretinopathy (AMN) following an Influenza A virus infection during Long COVID who experienced severe inflammation symptoms and ocular complications. We hypothesize that the rare occurrence of AMN in this patient could be associated with the immune storm secondary to the viral infection during Long COVID.

Keywords: inflammation; microvascular endothelial dysfunction; neutrophil extracellular trap; retinal diseases; retinoic acid depletion syndrome; virus infection.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

COVID-19* / complications
Female
Humans
Influenza A virus*
Post-Acute COVID-19 Syndrome
SARS-CoV-2
Virus Diseases*
White Dot Syndromes*

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. The Scientific Research Promotion Program of “Xinglin Scholars” in 2022(XKTD2022005).