Polarity-dominated chitosan biguanide hydrochloride-based nanofibrous membrane with antibacterial activity for long-lasting air filtration

Int J Biol Macromol. 2024 Jan;254(Pt 1):127729. doi: 10.1016/j.ijbiomac.2023.127729. Epub 2023 Oct 28.

Abstract

Facemasks play a significant role as personal protective equipment during the COVID-19 pandemic, but their longevity is limited by the easy dissipation of electrostatic charge and the accumulation of bacteria. In this study, nanofibrous membranes composed of polyacrylonitrile and chitosan biguanide hydrochloride (PAN@CGH) with remarkable antibacterial characteristics were prepared through the coaxial electrospinning process. Particulate matter could be efficiently captured by the fibrous membrane, up to 98 % or more, via polarity-dominated forces derived from cyano and amino groups. As compared commercial N95 masks, the PAN@CGH was more resistant to a wider variety of disinfection protocols. Additionally, the nanofibrous membrane could kill >99.99 % of both Escherichia coli and Staphylococcus aureus. Based on these characteristics, PAN@CGH nanofibrous membrane was applied to facial mask, which possessed an excellent and long-lasting effect on the capture of airborne particles. This work may be one of the most promising strategies on designing high-performance face masks for public health protection.

Keywords: Air filtration; Antibacterial; Nanofibrous membrane.

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use
  • Biguanides / pharmacology
  • Chitosan* / pharmacology
  • Escherichia coli
  • Filtration
  • Humans
  • Nanofibers*
  • Pandemics

Substances

  • Chitosan
  • Biguanides
  • Anti-Bacterial Agents