Paediatric pustulotic arthro-osteitis patient with an IL36RN variant, heterozygous c.115+6T>C, who was successfully treated with tonsillectomy: A case report and literature review

Kenji Takami; Shigeyoshi Tsuji; Ryu Jokoji; Yukari Okubo; Mari Higashiyama

doi:10.1111/exd.15016

Paediatric pustulotic arthro-osteitis patient with an IL36RN variant, heterozygous c.115+6T>C, who was successfully treated with tonsillectomy: A case report and literature review

Exp Dermatol. 2024 Jan;33(1):e15016. doi: 10.1111/exd.15016.

Authors

Kenji Takami¹, Shigeyoshi Tsuji^{2

3}, Ryu Jokoji⁴, Yukari Okubo⁵, Mari Higashiyama^{3

6}

Affiliations

¹ Department of Orthopaedic Surgery, Nippon Life Hospital, Osaka, Japan.
² Department of Rehabilitation, Nippon Life Hospital, Osaka, Japan.
³ Department of Psoriasis Center, Nippon Life Hospital, Osaka, Japan.
⁴ Department of Pathology, Nippon Life Hospital, Osaka, Japan.
⁵ Department of Dermatology, Tokyo Medical University, Tokyo, Japan.
⁶ Department of Dermatology, Nippon Life Hospital, Osaka, Japan.

PMID: 38284206
DOI: 10.1111/exd.15016

Abstract

Pustulotic arthro-osteitis (PAO) is an infrequent condition, with its manifestation in children being even rare. Some reports propose an association between genetic variants and the onset of PAO. Currently, no definitive treatment protocol exists for paediatric patients with PAO. In this study, we present the paediatric case of PAO with an IL36RN variant who was successfully treated with tonsillectomy.

Keywords: IL36RN variant; case report; paediatric-onset; pustulotic arthro-osteitis; tonsillectomy.

Publication types

Review
Case Reports

MeSH terms

Child
Humans
Interleukins
Osteitis* / etiology
Psoriasis* / complications
Tonsillectomy* / adverse effects

Substances

IL36RN protein, human
Interleukins