Circular RNA-mediated miRNA sponge & RNA binding protein in biological modulation of breast cancer

Jing Zhu; Qian Li; Zhongping Wu; Wei Xu; Rilei Jiang

doi:10.1016/j.ncrna.2023.12.005

Circular RNA-mediated miRNA sponge & RNA binding protein in biological modulation of breast cancer

Noncoding RNA Res. 2024 Jan 3;9(1):262-276. doi: 10.1016/j.ncrna.2023.12.005. eCollection 2024 Mar.

Authors

Jing Zhu¹, Qian Li², Zhongping Wu¹, Wei Xu³, Rilei Jiang¹

Affiliations

¹ School of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
² Medical Department, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
³ School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.

Abstract

Circular RNAs (circRNAs) and small non-coding RNAs of the head-to-junction circle in the construct play critical roles in gene regulation and are significantly associated with breast cancer (BC). Numerous circRNAs are potential cancer biomarkers that may be used for diagnosis and prognosis. Widespread expression of circRNAs is regarded as a feature of gene expression in highly diverged eukaryotes. Recent studies show that circRNAs have two main biological modulation models: sponging and RNA-binding. This review explained the biogenesis of circRNAs and assessed emerging findings on their sponge function and role as RNA-binding proteins (RBPs) to better understand how their interaction alters cellular function in BC. We focused on how sponges significantly affect the phenotype and progression of BC. We described how circRNAs exercise the translation functions in ribosomes. Furthermore, we reviewed recent studies on RBPs, and post-protein modifications influencing BC and provided a perspective on future research directions for treating BC.

Keywords: Biogenesis; Breast cancer; CircRNAs; RNA-Binding proteins (RBPs); Sponge.

Publication types

Review