Plant-produced Der p 2-bearing bioparticles activate Th1/Treg-related activation patterns in dendritic cells irrespective of the allergic background

Stefanie Busold; Lorenz Aglas; Charlotte Menage; Réjean Desgagnés; Loïc Faye; Anne-Catherine Fitchette; Esther C de Jong; Caroline Martel; Maria Stigler; Virginie Catala-Stordeur; Guy Tropper; Lydia Auger; Bertrand Morel; Serge A Versteeg; Louis-P Vézina; Véronique Gomord; Janice A Layhadi; Mohamed Shamji; Teunis B H Geijtenbeek; Ronald van Ree

doi:10.1111/cea.14456

Plant-produced Der p 2-bearing bioparticles activate Th1/Treg-related activation patterns in dendritic cells irrespective of the allergic background

Clin Exp Allergy. 2024 Apr;54(4):300-303. doi: 10.1111/cea.14456. Epub 2024 Jan 27.

Authors

Stefanie Busold^{1

2}, Lorenz Aglas³, Charlotte Menage^{1

2}, Réjean Desgagnés⁴, Loïc Faye⁵, Anne-Catherine Fitchette⁵, Esther C de Jong^{1

2}, Caroline Martel⁴, Maria Stigler³, Virginie Catala-Stordeur⁵, Guy Tropper⁴, Lydia Auger⁴, Bertrand Morel⁵, Serge A Versteeg^{1

2}, Louis-P Vézina⁴, Véronique Gomord^{4

5}, Janice A Layhadi⁶, Mohamed Shamji⁶, Teunis B H Geijtenbeek^{1

2}, Ronald van Ree^{1

7}

Affiliations

¹ Department of Experimental Immunology, Amsterdam Institute for Infection & Immunology, Amsterdam University Medical Centers, location AMC, Amsterdam, The Netherlands.
² Amsterdam Institute for Infection and Immunity, Inflammatory Diseases, Amsterdam, The Netherlands.
³ Department of Biosciences and Medical Biology, University of Salzburg, Salzburg, Austria.
⁴ Angany Inc., Québec City, Quebec, Canada.
⁵ Angany Innovation, Val de Reuil, France.
⁶ National Heart & Lung Institute, Imperial College London, London, UK.
⁷ Department of Otorhinolaryngology, Amsterdam University Medical Centers, location AMC, Amsterdam, The Netherlands.

PMID: 38279775
DOI: 10.1111/cea.14456

No abstract available

Keywords: Der p 2; allergen immunotherapy; allergic status; dendritic cell activation; hypoallergenicity; microparticles; plant‐made bioparticles; structural adjuvant.

MeSH terms

Allergens
Antigens, Dermatophagoides
Arthropod Proteins
Cytokines
Dendritic Cells
Humans
Hypersensitivity*
T-Lymphocytes, Regulatory*

Substances

Dermatophagoides pteronyssinus antigen p 2
Antigens, Dermatophagoides
Arthropod Proteins
Allergens
Cytokines

MeSH terms

Substances

Grants and funding