Unlocking CAR T cell potential: Inosine-induced stemness and enhanced potency

Xingying Zhang; Haoyi Wang

doi:10.1016/j.ccell.2024.01.003

Unlocking CAR T cell potential: Inosine-induced stemness and enhanced potency

Cancer Cell. 2024 Feb 12;42(2):175-177. doi: 10.1016/j.ccell.2024.01.003. Epub 2024 Jan 25.

Authors

Xingying Zhang¹, Haoyi Wang²

Affiliations

¹ State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 100101 Beijing, China.
² State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 100101 Beijing, China; University of Chinese Academy of Sciences, 100049 Beijing, China; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China. Electronic address: wanghaoyi@ioz.ac.cn.

PMID: 38278148
DOI: 10.1016/j.ccell.2024.01.003

Abstract

Adenosine (Ado) drives immune suppression in the tumor microenvironment. In this issue of Cancer Cell, Klysz et al. investigate Ado-mediated immunosuppression. Overexpression of Ado deaminase (ADA-OE), metabolizing Ado to inosine (INO), induces stemness and improves CAR T cell functionality. Likewise, exposure to INO enhances CAR T cells' function and induces stemness features.

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MeSH terms

Adenosine*
Humans
Inosine* / pharmacology
T-Lymphocytes

Substances

Inosine
Adenosine