Interdisciplinary Collaboration on Real World Data to Close the Knowledge Gap: A Reflection on "De Sutter et al. Predicting Volume of Distribution in Neonates: Performance of Physiologically Based Pharmacokinetic Modelling"

Karel Allegaert; Anne Smits; Pieter Annaert

doi:10.3390/pharmaceutics16010128

Interdisciplinary Collaboration on Real World Data to Close the Knowledge Gap: A Reflection on "De Sutter et al. Predicting Volume of Distribution in Neonates: Performance of Physiologically Based Pharmacokinetic Modelling"

Pharmaceutics. 2024 Jan 19;16(1):128. doi: 10.3390/pharmaceutics16010128.

Authors

Karel Allegaert^{1

2

3}, Anne Smits^{2

4}, Pieter Annaert⁵

Affiliations

¹ Clinical Pharmacology and Pharmacotherapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium.
² Department of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium.
³ Department of Hospital Pharmacy, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands.
⁴ Neonatal Intensive Care Unit, University Hospitals Leuven, 3000 Leuven, Belgium.
⁵ Drug Delivery and Disposition, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium.

Abstract

This commentary further reflects on the paper of De Sutter et al. on predicting volume of distribution in neonates, and the performance of physiologically based pharmacokinetic models We hereby stressed the add on value to collaborate on real world data to further close this knowledge gap. We illustrated this by weight distribution characteristics in breastfed (physiology) and in asphyxiated (pathophysiology), with additional reflection on their kidney and liver function.

Keywords: allometric scaling; developmental pharmacology; neonates; pharmacokinetics; physiologically based pharmacokinetics (PBPK); real world data; volume of distribution.

Abstract

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