Iron accumulation and lipid peroxidation: implication of ferroptosis in hepatocellular carcinoma

Xiaodong Li; Fanguang Meng; Hankang Wang; Liwei Sun; Shulin Chang; Guijie Li; Feng Chen

doi:10.3389/fendo.2023.1319969

Iron accumulation and lipid peroxidation: implication of ferroptosis in hepatocellular carcinoma

Front Endocrinol (Lausanne). 2024 Jan 4:14:1319969. doi: 10.3389/fendo.2023.1319969. eCollection 2023.

Authors

Xiaodong Li^{1

2}, Fanguang Meng^{1

2}, Hankang Wang^{1

2}, Liwei Sun^{1

2}, Shulin Chang^{1

2}, Guijie Li¹, Feng Chen¹

Affiliations

¹ Department of Radiology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Abdominal Medicine Imaging, Jinan, China.
² Graduate School, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China.

Abstract

Ferroptosis is a type of controlled cell death caused by lipid peroxidation, which results in the rupture of the cell membrane. ferroptosis has been repeatedly demonstrated over the past ten years to be a significant factor in a number of diseases. The liver is a significant iron storage organ, thus ferroptosis will have great potential in the treatment of liver diseases. Ferroptosis is particularly prevalent in HCC. In the opening section of this article, we give a general summary of the pertinent molecular mechanisms, signaling pathways, and associated characteristics of ferroptosis. The primary regulating mechanisms during ferroptosis are then briefly discussed, and we conclude by summarizing the development of a number of novel therapeutic strategies used to treat HCC in recent years. Ferroptosis is a crucial strategy for the treatment of HCC and offers new perspectives on the treatment of liver cancer.

Keywords: chemotherapy; drug resistance; ferroptosis; hepatocellular carcinoma; therapy.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Carcinoma, Hepatocellular*
Ferroptosis*
Humans
Iron
Lipid Peroxidation
Liver Neoplasms*

Substances

Iron

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was funded by the Natural Science Foundation of Shandong Province (grant no. ZR2019BH041 to FC and no. ZR2023MH120 to GL), the Nature Science Foundation of China (grant no. 81803008 to FC) and the cultivating fund of the First hospital of Shandong First Medical University (grant no. QYPY2021NSFC0616 to FC).