A comprehensive review of Cornus officinalis: health benefits, phytochemistry, and pharmacological effects for functional drug and food development

Wenhui Deng; Yuchen Liu; Yaodong Guo; Jie Chen; Hassan Idris Abdu; Muhmmad R U Khan; Chella Perumal Palanisamy; Jinjin Pei; A M Abd El-Aty

doi:10.3389/fnut.2023.1309963

A comprehensive review of Cornus officinalis: health benefits, phytochemistry, and pharmacological effects for functional drug and food development

Front Nutr. 2024 Jan 11:10:1309963. doi: 10.3389/fnut.2023.1309963. eCollection 2023.

Authors

Wenhui Deng^#¹, Yuchen Liu^#², Yaodong Guo^{3

4}, Jie Chen^{3

4}, Hassan Idris Abdu^{3

4}, Muhmmad R U Khan^{2

3

4

5}, Chella Perumal Palanisamy², Jinjin Pei², A M Abd El-Aty^{6

7}

Affiliations

¹ College of Physical Education, Shaanxi University of Technology, Hanzhong, China.
² Shaanxi Province Key Laboratory of Bioresources, QinLing-Bashan Mountains Bioresources Comprehensive Development C. I. C., Qinba State Key Laboratory of Biological Resources and Ecological Environment, College of Bioscience and Bioengineering, Shaanxi University of Technology, Hanzhong, Shaanxi, China.
³ College of Health Management, Shangluo University, Shangluo, Shaanxi, China.
⁴ ShaanxiUnion Research Center of University and Enterprise for Health Food Ingredient and Walnut Industry, Shangluo, Shaanxi, China.
⁵ Pak-Austria Fachhochschule lnstitute of Applied Sciences and Technology, Haripur, Pakistan.
⁶ Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
⁷ Department of Medical Pharmacology, Faculty of Medicine, Atatürk University, Erzurum, Türkiye.

^# Contributed equally.

Abstract

Introduction: Cornus officinalis sieb. et zucc, a deciduous tree or shrub, is renowned for its "Cornus flesh" fruit, which is widely acknowledged for its medicinal value when matured and dried. Leveraging C. officinalis as a foundational ingredient opens avenues for the development of environmentally friendly health foods, ranging from beverages and jams to preserves and canned products. Packed with diverse bioactive compounds, this species manifests a spectrum of pharmacological effects, including anti-inflammatory, antioxidant, antidiabetic, immunomodulatory, neuroprotective, and cardiovascular protective properties.

Methods: This study employs CiteSpace visual analysis software and a bibliometric analysis platform, drawing upon the Web of Science (WOS) database for literature spanning the last decade. Through a comprehensive analysis of available literature from WOS and Google Scholar, we present a thorough summary of the health benefits, phytochemistry, active compounds, and pharmacological effects of C. officinalis. Particular emphasis is placed on its potential in developing functional drugs and foods.

Results and discussion: While this review enhances our understanding of C. officinalis as a prospective therapeutic agent, its clinical applicability underscores the need for further research and clinical studies to validate findings and establish safe and effective clinical applications.

Keywords: Cornaceae; Cornus officinalis; biological activity; health characteristics; pharmacological effects.

Publication types

Systematic Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was funded by the Key Basic Research Project of Shaanxi Provincial Department of Science and Technology (2023-JC-ZD-13), the Special Support Plan for High-Level Talents in Shaanxi Province (for JP), the Foreign Expert Project of the Ministry of Science and Technology, and the Project for Scientific and Technological Innovation Team in Shangluo City of Shaanxi Province (SK2019-72).