Immune Effects of Intra-Arterial Liver-Directed Therapies

Anita Karimi; Hooman Yarmohammadi; Joseph P Erinjeri

doi:10.1016/j.jvir.2023.10.019

Immune Effects of Intra-Arterial Liver-Directed Therapies

J Vasc Interv Radiol. 2024 Feb;35(2):178-184. doi: 10.1016/j.jvir.2023.10.019.

Authors

Anita Karimi¹, Hooman Yarmohammadi¹, Joseph P Erinjeri²

Affiliations

¹ Interventional Radiology Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
² Interventional Radiology Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York. Electronic address: Erinjerj@mskcc.org.

PMID: 38272638
DOI: 10.1016/j.jvir.2023.10.019

Abstract

Image-guided intra-arterial locoregional therapies (LRTs) such as transarterial embolization, transarterial chemoembolization, and transarterial radioembolization exhibit effects on the immune system. Understanding the humoral (cytokine, chemokine, and growth factor) and cellular (T cell, neutrophil, dendritic cell, and macrophage) mechanisms underlying the immune effects of LRT is crucial to designing rational and effective combinations of immunotherapy and interventional radiology procedures. This article aims to review the immune effects of intra-arterial LRTs and provide insight into strategies to combine LRTs with systemic immunotherapy.

Publication types

Review

MeSH terms

Carcinoma, Hepatocellular* / therapy
Chemoembolization, Therapeutic* / methods
Humans
Liver Neoplasms* / diagnostic imaging
Liver Neoplasms* / radiotherapy
Vascular Surgical Procedures