Nanocellulose-based platforms as a multipurpose carrier for drug and bioactive compounds: From active packaging to transdermal and anticancer applications

Abstract

The nanocellulose has unique characteristics, such as biocompatibility, good mechanical strength, and low cytotoxicity. The nanocellulose crystalline portion is responsible for good mechanical resistance, while the amorphous portion is responsible for flexibility. Such features make it a promising candidate for multiple applications related to the modulation of substance release: targeted cancer therapy, transdermal drug delivery, and controlled-release packaging materials. Thus, in this study, we discussed nanocellulose as a multipurpose material for drug delivery and bioactive compound carriers in controlled delivery systems with varied applications in pharmaceutic fields. Herein, we focus on understanding key factors such as i) polymer-drug interactions and surface modification strategies in controlled release rates, ii) therapeutic efficacy, and iii) biocompatibility aspects. The tunable chemistry surface plays a fundamental approach limiting the quick release of active substances in drug delivery systems. Several works on a pre-clinical stage of investigation were overviewed, reporting robust evidence on nanocellulose to design bioactive compounds/drug delivery carriers based on stimuli-responsive drug release and controlled delivery systems for higher efficiency in cancer therapies, purposing target therapy and reduced side effects. Nanocellulose was also identified as a solid candidate material in active packaging for pharmaceutical products. Cellulose nanocrystals and bacterial cellulose demonstrated strong potential to overcome the challenge of controlled release profile and open novel insights in advanced active packaging materials for pharmaceutics with controlled release of antioxidant and antimicrobial substances. Moreover, the concept overview in this work might be extended in active food packaging technologies to flavor-releasing/absorbing systems or antimicrobial/antioxidant carriers for extending the shelf life of foods.

Keywords: Bacterial nanocellulose; Cellulose nanocrystals; Cellulose nanofibrils; Microfibrillated cellulose; Neo-adjuvants; Wound dressing.