Structural highlights of macromolecular complexes and assemblies

Brinda Vallat; Helen M Berman

doi:10.1016/j.sbi.2023.102773

Structural highlights of macromolecular complexes and assemblies

Curr Opin Struct Biol. 2024 Apr:85:102773. doi: 10.1016/j.sbi.2023.102773. Epub 2024 Jan 24.

Authors

Brinda Vallat¹, Helen M Berman²

Affiliations

¹ Research Collaboratory for Structural Bioinformatics Protein Data Bank and the Institute for Quantitative Biomedicine, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA; Cancer Institute of New Jersey, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA. Electronic address: brinda.vallat@rcsb.org.
² Research Collaboratory for Structural Bioinformatics Protein Data Bank and the Institute for Quantitative Biomedicine, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA; Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA; Department of Quantitative and Computational Biology, University of Southern California, Los Angeles CA 90089, USA.

PMID: 38271778
DOI: 10.1016/j.sbi.2023.102773

Abstract

The structures of macromolecular assemblies have given us deep insights into cellular processes and have profoundly impacted biological research and drug discovery. We highlight the structures of macromolecular assemblies that have been modeled using integrative and computational methods and describe how open access to these structures from structural archives has empowered the research community. The arsenal of experimental and computational methods for structure determination ensures a future where whole organelles and cells can be modeled.

Keywords: AlphaFold; Computational modeling; Computed structure models; IHMCIF; Integrative modeling; ModelArchive; ModelCIF; PDB; PDB-Dev; PDBx/mmCIF; Protein structure prediction; RoseTTAFold.

Publication types

Review

MeSH terms

Databases, Protein
Drug Discovery*
Macromolecular Substances / chemistry
Models, Molecular

Substances

Macromolecular Substances