A Systems Approach to Biomechanics, Mechanobiology, and Biotransport

Shayn M Peirce-Cottler; Edward A Sander; Matthew B Fisher; Alix C Deymier; John F LaDisa Jr; Grace O'Connell; David T Corr; Bumsoo Han; Anita Singh; Sara E Wilson; Victor K Lai; Alisa Morss Clyne

doi:10.1115/1.4064547

A Systems Approach to Biomechanics, Mechanobiology, and Biotransport

J Biomech Eng. 2024 Apr 1;146(4):040801. doi: 10.1115/1.4064547.

Authors

Affiliations

¹ Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22903.
² Roy J. Carver Department of Biomedical Engineering, College of Engineering, 5629 Seamans Center, University of Iowa, Iowa City, IA 52242; Department of Orthopedics and Rehabilitation, Carver College of Medicine, University of Iowa, Iowa City, IA 52242.
³ Joint Department of Biomedical Engineering, North Carolina State University, Raleigh, NC 27695; Joint Department of Biomedical Engineering, University of North Carolina-Chapel Hill, Chapel Hill, NC 27514.
⁴ Department of Biomedical Engineering, University of Connecticut Health, Farmington, CT 06032.
⁵ Department of Biomedical Engineering, Marquette University and the Medical College of Wisconsin, Wauwatosa, WI 53226; Department of Pediatrics, Division of Cardiology Herma Heart Institute, Children's Wisconsin and the Medical College of Wisconsin, Milwaukee, WI 53226.
⁶ Department of Mechanical Engineering, University of California-Berkeley, 6141 Etcheverry Hall, Berkeley, CA 94720.
⁷ Department of Biomedical Engineering, Center for Modeling, Simulation, & Imaging in Medicine, Rensselaer Polytechnic Institute, 7042 Jonsson Engineering Center 110 8th Street, Troy, NY 12180.
⁸ School of Mechanical Engineering, Purdue University, 585 Purdue Mall, West Lafayette, IN 47907; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907; Center for Cancer Research, Purdue University, 585 Purdue Mall, West Lafayette, IN 47907.
⁹ Purdue University West Lafayette.
¹⁰ Bioengineering Department, Temple University, Philadelphia, PA 19122.
¹¹ Department of Mechanical Engineering, University of Kansas, 1530 W 15th Street, Lawrence, KS 66045.
¹² Department of Chemical Engineering, University of Minnesota Duluth, Duluth, MN 55812.
¹³ Fischell Department of Bioengineering, University of Maryland, 8278 Paint Branch Drive, College Park, MD 20742.

PMID: 38270930
DOI: 10.1115/1.4064547

Abstract

The human body represents a collection of interacting systems that range in scale from nanometers to meters. Investigations from a systems perspective focus on how the parts work together to enact changes across spatial scales, and further our understanding of how systems function and fail. Here, we highlight systems approaches presented at the 2022 Summer Biomechanics, Bio-engineering, and Biotransport Conference in the areas of solid mechanics; fluid mechanics; tissue and cellular engineering; biotransport; and design, dynamics, and rehabilitation; and biomechanics education. Systems approaches are yielding new insights into human biology by leveraging state-of-the-art tools, which could ultimately lead to more informed design of therapies and medical devices for preventing and treating disease as well as rehabilitating patients using strategies that are uniquely optimized for each patient. Educational approaches can also be designed to foster a foundation of systems-level thinking.

MeSH terms

Bioengineering*
Biomechanical Phenomena
Biophysics
Humans
Systems Analysis*

Grants and funding

R13 EB033191/EB/NIBIB NIH HHS/United States