Kikuchi-Fujimoto Disease in Human Leukocyte Antigen Partially Matched Siblings: A Case Study of Familial Susceptibility

Atsushi Isoda; Kenichi Tahara; Munenori Ide

doi:10.7759/cureus.51010

Kikuchi-Fujimoto Disease in Human Leukocyte Antigen Partially Matched Siblings: A Case Study of Familial Susceptibility

Cureus. 2023 Dec 23;15(12):e51010. doi: 10.7759/cureus.51010. eCollection 2023 Dec.

Authors

Atsushi Isoda¹, Kenichi Tahara², Munenori Ide³

Affiliations

¹ Department of Hematology, Iryohojin Hoshiiin, Maebashi, JPN.
² Department of Hematology, Maebashi Red Cross Hospital, Maebashi, JPN.
³ Department of Pathology, Maebashi Red Cross Hospital, Maebashi, JPN.

Abstract

Kikuchi-Fujimoto disease (KFD) is a rare and self-limiting disorder that predominantly affects young individuals of Asian descent. This case report describes familial KFD in partially human leukocyte antigen (HLA)-matched siblings. An adolescent male presented with cervical lymphadenopathy and elevated lactate dehydrogenase (LDH) levels, diagnosed by biopsy as KFD; approximately one year later, his sister presented with similar symptoms. Both siblings were found to carry the HLA-DPB1*0202 allele, which is commonly associated with KFD. These cases highlight a genetic component in KFD and encourage further genetic research to delineate the pathogenesis of the disease.

Keywords: familial susceptibility; histiocytic necrotizing lymphadenitis; human leukocyte antigen; kikuchi-fujimoto disease; sibling.

Publication types

Case Reports