Dyskinesia-hyperpyrexia syndrome in Parkinson's disease triggered by overdose of levodopa - a case report and literature review

Xiangnan Du; Xuemei Wang; Xiaokun Geng

doi:10.3389/fneur.2023.1323717

Dyskinesia-hyperpyrexia syndrome in Parkinson's disease triggered by overdose of levodopa - a case report and literature review

Front Neurol. 2024 Jan 5:14:1323717. doi: 10.3389/fneur.2023.1323717. eCollection 2023.

Authors

Xiangnan Du¹, Xuemei Wang¹, Xiaokun Geng^{1

2}

Affiliations

¹ Department of Neurology, Beijing Luhe Hospital, Capital Medical University, Beijing, China.
² China-America Institute of Neuroscience, Department of Neurology, Beijing Luhe Hospital, Capital Medical University, Beijing, China.

Abstract

Dyskinesia-hyperpyrexia syndrome, a rare medical emergency in Parkinson's disease, is first described in 2010. It is characterized by severe continuous dyskinesia associated with rhabdomyolysis, hyperthermia and subsequent alteration of the mental state. Gradual reduction of dopaminergic dose or DBS is recommended treatment. The prognosis is usually good, but sometimes fatal. But so far, this potentially fatal complication is not widely recognized by clinicians. In emergency, if clinicians fail to make prompt diagnosis and treatment, patients' conditions may get worse, and their lives may be threatened in serious cases.

Keywords: Parkinson's disease; acute hyperpyrexia syndrome; dyskinesia; hyperpyrexia; treatment.

Publication types

Case Reports

Grants and funding

The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.