Neuronal dysfunction and gene modulation by non-coding RNA in Parkinson's disease and synucleinopathies

Rosaria Meccariello; Gian Carlo Bellenchi; Salvatore Pulcrano; Sebastian Luca D'Addario; Domenico Tafuri; Nicola B Mercuri; Ezia Guatteo

doi:10.3389/fncel.2023.1328269

Neuronal dysfunction and gene modulation by non-coding RNA in Parkinson's disease and synucleinopathies

Front Cell Neurosci. 2024 Jan 5:17:1328269. doi: 10.3389/fncel.2023.1328269. eCollection 2023.

Authors

Rosaria Meccariello^#¹, Gian Carlo Bellenchi^#^{2

3}, Salvatore Pulcrano², Sebastian Luca D'Addario^{3

4

5}, Domenico Tafuri¹, Nicola B Mercuri^{3

5

6}, Ezia Guatteo^{1

3

5}

Affiliations

¹ Department of Medical and Movement Sciences and Wellness, University of Naples Parthenope, Naples, Italy.
² Institute of Genetics and Biophysics, CNR, Naples, Italy.
³ Experimental Neurology Laboratory, Santa Lucia Foundation IRCCS, Rome, Italy.
⁴ Computational and Translational Neuroscience Laboratory, Institute of Cognitive Sciences and Technologies, CNR, Rome, Italy.
⁵ Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, United States.
⁶ Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.

^# Contributed equally.

Abstract

Over the last few decades, emerging evidence suggests that non-coding RNAs (ncRNAs) including long-non-coding RNA (lncRNA), microRNA (miRNA) and circular-RNA (circRNA) contribute to the molecular events underlying progressive neuronal degeneration, and a plethora of ncRNAs have been identified significantly misregulated in many neurodegenerative diseases, including Parkinson's disease and synucleinopathy. Although a direct link between neuropathology and causative candidates has not been clearly established in many cases, the contribution of ncRNAs to the molecular processes leading to cellular dysfunction observed in neurodegenerative diseases has been addressed, suggesting that they may play a role in the pathophysiology of these diseases. Aim of the present Review is to overview and discuss recent literature focused on the role of RNA-based mechanisms involved in different aspects of neuronal pathology in Parkinson's disease and synucleinopathy models.

Keywords: Parkinson’s disease; circRNA; dopamine neurons; lncRNA; miRNA; ncRNA; synucleinopathy; α-synuclein.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of the article. This Review was supported in whole or in part by the Aligning Science Across Parkinson’s [ASAP-020505] through the Michael J. Fox Foundation for Parkinson’s Research (MJFF). For the purpose of open access, the author has applied a CC-BY 4.0 public copyright license to all Author Accepted Manuscripts arising from this submission. Additional funding source: Ministry of University and Research, DM 737 (dated June 25, 2021)—Fondo per la promozione e lo sviluppo delle politiche del Programma Nazionale per la Ricerca to EG.