Endometriosis diagnosed by ultrasound is associated with lower live birth rates in women undergoing their first in vitro fertilization/intracytoplasmic sperm injection treatment

Fertil Steril. 2024 May;121(5):832-841. doi: 10.1016/j.fertnstert.2024.01.023. Epub 2024 Jan 19.

Abstract

Objective: To study the cumulative live birth rate (CLBR) after the first in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment in women with or without deep-infiltrating endometriosis (DIE) and/or endometrioma diagnosed by transvaginal ultrasonography (TVUS), using the International Deep Endometriosis Analysis (IDEA) group definitions.

Design: Prospective observational cohort study at a university hospital.

Patients(s): In total, 1,040 women with subfertility aged 25 to ≤39 years were undergoing their first IVF/ICSI treatment between January 2019 and October 2022. Of these, 234 (22.5%; 95% confidence interval [CI], 20.0-25.0) women were diagnosed with DIE and/or endometrioma at systematic TVUS before starting their treatment.

Intervention(s): All women underwent their first IVF or ICSI treatment. Fresh and/or frozen embryos from the first cycle were used until pregnancy was achieved or no embryos remained.

Main outcome measure(s): Cumulative live birth rate after the first IVF/ICSI cycle in women with or without DIE and/or endometrioma.

Result(s): The CLBR after the first IVF/ICSI treatment in the total cohort of women was 426/1,040 (41.0%; 95% CI, 38.0-44.0). Women with DIE and/or endometrioma had a lower CLBR (78/234, 33.3%; 95% CI, 27.3-39.4) than women without the disease (348/806, 43.2%; 95% CI, 39.8-46.6). The crude relative risk (RR) for cumulative live birth for women with DIE and/or endometrioma was 0.77; 95% CI, 0.63-0.94, and after adjustments were made for age, body mass index, s-antimüllerian hormone, stimulation protocol, and day for embryo transfer, the adjusted RR was 0.63; 95% CI, 0.48-0.82. There was no difference in the number of retrieved mature oocytes, fertilization rate, or good quality embryos between the 2 groups.

Conclusion: The presence of DIE and/or endometrioma diagnosed by TVUS lowers the chance of live birth in women undergoing their first IVF/ICSI treatment.

Keywords: Ultrasound; assisted reproductive treatment; cumulative live birth rate; deep-infiltrating endometriosis; endometrioma.

Publication types

  • Observational Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Birth Rate
  • Endometriosis* / diagnosis
  • Endometriosis* / diagnostic imaging
  • Endometriosis* / epidemiology
  • Endometriosis* / therapy
  • Female
  • Fertilization in Vitro*
  • Humans
  • Infertility, Female / diagnostic imaging
  • Infertility, Female / epidemiology
  • Infertility, Female / therapy
  • Live Birth*
  • Pregnancy
  • Pregnancy Rate
  • Prospective Studies
  • Sperm Injections, Intracytoplasmic*
  • Treatment Outcome
  • Ultrasonography