Getting to know ovarian cancer: Focusing on the effect of LncRNAs in this cancer and the effective signaling pathways

Abdullah Ali Alzahrani; Yasir Qasim Almajidi; Saade Abdalkareem Jasim; Ahmed Hjazi; Bokov Dmitry Olegovich; Adnan Taan Alkhafaji; Hussam Abdali Abdulridui; Batool Ali Ahmed; Ahmed Alawadi; Ali Alsalamy

doi:10.1016/j.prp.2023.155084

Getting to know ovarian cancer: Focusing on the effect of LncRNAs in this cancer and the effective signaling pathways

Pathol Res Pract. 2024 Feb:254:155084. doi: 10.1016/j.prp.2023.155084. Epub 2024 Jan 4.

Affiliations

¹ Department of Surgery, Taif Univetsity, Saudi Arabia.
² Baghdad College of Medical Sciences-Department of Pharmacy, Baghdad, Iraq. Electronic address: almajidiyasir@gmail.com.
³ Medical Laboratory Techniques Department, Al-maarif University College , Anbar, Iraq. Electronic address: saadejasim2023@gmail.com.
⁴ Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Saudi Arabia.
⁵ Institute of Pharmacy, Moscow Medical University, Moscow, Russian Federation; Laboratory of Food Chemistry, Federal Research Center of Nutrition, Biotechnology and Food Safety, Moscow, Russian Federation.
⁶ Cardiology Department, College of Medicine, Al-Ayen University, Thi-Qar, Iraq.
⁷ Department of medical engineering, Al-Hadi University College, Iraq.
⁸ Department of Medical Engineering, Al-Nisour University College, Baghdad, Iraq.
⁹ College of technical engineering, the Islamic University, Najaf, Iraq; College of technical engineering, the Islamic University of Al Diwaniyah, Iraq; College of technical engineering, the Islamic University of Babylon, Iraq.
¹⁰ College of technical engineering, Imam Ja'afar Al-Sadiq University, Iraq.

PMID: 38244434
DOI: 10.1016/j.prp.2023.155084

Abstract

This article undertakes a comprehensive investigation of ovarian cancer, examining the complex nature of this challenging disease. The main focus is on understanding the role of long non-coding RNAs (lncRNAs) in the context of ovarian cancer (OC), and their regulatory functions in disease progression. Through extensive research, the article identifies specific lncRNAs that play significant roles in the intricate molecular processes of OC. Furthermore, the study examines the signaling pathways involved in the development of OC, providing a detailed comprehension of the underlying molecular mechanisms. By connecting lncRNA dynamics with signaling pathways, this exploration not only advances our understanding of ovarian cancer but also reveals potential targets for therapeutic interventions. The findings open up opportunities for targeted treatments, highlighting the importance of personalized approaches in addressing this complex disease and driving progress in ovarian cancer research and treatment strategies.

Keywords: LncRNA- HOTAIR; LncRNAs; Ovarian cancers; Signaling pathways.

Publication types

Review

MeSH terms

Disease Progression
Female
Humans
Ovarian Neoplasms* / genetics
RNA, Long Noncoding* / genetics
RNA, Long Noncoding* / metabolism
Signal Transduction / genetics

Substances

RNA, Long Noncoding