A Comparison of the Decline in Glomerular Filtration Rate between Elderly Patients with Diabetes and those without Diabetes in Southwest China

Qing-Hua Yi; Hong-Liang Wang; Yun Hou; Lang Xu; Wei-Li Tian; Yi-Xuan Zhang; Yu-Shan Xu; Jia-Bin Shi

doi:10.2174/0118715303261963231228125548

A Comparison of the Decline in Glomerular Filtration Rate between Elderly Patients with Diabetes and those without Diabetes in Southwest China

Endocr Metab Immune Disord Drug Targets. 2024 Jan 11. doi: 10.2174/0118715303261963231228125548. Online ahead of print.

Authors

Qing-Hua Yi¹, Hong-Liang Wang¹, Yun Hou², Lang Xu², Wei-Li Tian², Yi-Xuan Zhang¹, Yu-Shan Xu³, Jia-Bin Shi⁴

Affiliations

¹ Department of Nephrology, Kunming Guandu District People's Hospital, Kunming 650200, China.
² Department of Internail Medicine, Community Health Service Center of Wujing Street, Guandu District, Kunming 650200, China.
³ Department of Internal Secretion, First Affiliated Hospital of Kunming Medical University, Kunming 650200, China.
⁴ Department of Logistics, Kunming Guandu District People's Hospital, Kunming 650200, China.

PMID: 38243974
DOI: 10.2174/0118715303261963231228125548

Abstract

Objective: To investigate the effect of high blood glucose on the decline in the estimated glomerular filtration rate (eGFR) in the elderly.

Methods: We compared the decline in eGFR of diabetic and non-diabetic groups in the noninterventional state and analyzed the effect of hyperglycemia on the decline in eGFR among the elderly in a retrospective analysis of 1,223 cases of elderly people aged 65 years or older with a 4-year follow-up period.

Results: The prevalence of diabetes in the elderly increased significantly from 12.67% in 2017 to 16.68% in 2021. The rate of decline in eGFR in patients with diabetes was higher than in the population without diabetes, at 9.29% and 5.32%, respectively (both p <0.05).

Conclusion: The results of this study revealed that the prevalence of diabetes in the elderly increased significantly, and there is a more rapid decrease in the eGFR levels in those with diabetes than those without diabetes.

Keywords: Diabetes; eGFR decline; elderly; inflammation.; non-intervention.