Highly sensitive sensing of DPA by lanthanide metal-organic frameworks and detection of fiber membranes

Qiongli Luo; Lei Wang; Shuangyan Wu; Lin Lin; Xiaolin Yu; Andrei Potapov; Yaguang Sun; Ying Zhang; Mingchang Zhu

doi:10.1016/j.saa.2024.123849

Highly sensitive sensing of DPA by lanthanide metal-organic frameworks and detection of fiber membranes

Spectrochim Acta A Mol Biomol Spectrosc. 2024 Apr 5:310:123849. doi: 10.1016/j.saa.2024.123849. Epub 2024 Jan 10.

Authors

Qiongli Luo¹, Lei Wang², Shuangyan Wu¹, Lin Lin³, Xiaolin Yu⁴, Andrei Potapov⁴, Yaguang Sun¹, Ying Zhang⁵, Mingchang Zhu⁶

Affiliations

¹ The Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry, Shenyang University of Chemical Technology, Shenyang, Liaoning 110142, PR China.
² Center of Physical Chemistry Test, Shenyang University of Chemical Technology, Shenyang, Liaoning 110142, PR China.
³ Department of Pharmacology, Shenyang medical colleges, Shenyang 110034, PR China.
⁴ Nikolaev Institute of Inorganic Chemistry, Siberian Branch of the Russian Academy of Sciences, 3 Lavrentiev Ave., 630090 Novosibirsk, Russia.
⁵ The Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry, Shenyang University of Chemical Technology, Shenyang, Liaoning 110142, PR China. Electronic address: zhangy621@syuct.edu.cn.
⁶ The Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry, Shenyang University of Chemical Technology, Shenyang, Liaoning 110142, PR China. Electronic address: mczhu@syuct.edu.cn.

PMID: 38241931
DOI: 10.1016/j.saa.2024.123849

Abstract

The detection of 2,6-pyridinecarboxylic acid (DPA), as a biomarker of Bacillus anthracis, has attracted wide attention. In previous reports of DPA detection, fluorescent probes may not have high specificity. Therefore, the rational design and development of fluorescent sensors with excellent performance is of great significance for the detection of DPA. In this study, two novel lanthanide metal-organic frameworks (Ln-MOFs) were synthesized by hydrothermal method using 3-polyfluorobiphenyl-3 ', 4,5 ' -tricarboxylic acid (H2FPTA) as ligand. Studies have shown that Ln-MOFs can detect DPA in real time, with detection limits of 0.54 μM and 0.67 μM, respectively, and have a high recovery rate (95 % -108 %) in fetal bovine serum. As a self-calibration sensor, other substances in the blood can be clearly distinguished by a two-dimensional fluorescence code diagram. After the Ln-MOFs were spun into nanofiber membranes, they responded quickly to DPA. This increases practicability and provides a promising idea for the development of simple and efficient ratio sensors.

Keywords: DPA; Fiber membrane detection; Self-calibration sensor.

MeSH terms

Bacillus anthracis*
Fluorescence
Fluorescent Dyes
Lanthanoid Series Elements*
Metal-Organic Frameworks*

Substances

Lanthanoid Series Elements
Metal-Organic Frameworks
Fluorescent Dyes