Recent advances in functionalized ferrite nanoparticles: From fundamentals to magnetic hyperthermia cancer therapy

Linxue Zhang; Qifan Li; Junxiao Liu; Zunyi Deng; Xueliang Zhang; Nuernisha Alifu; Xiaofeng Zhang; Zhong Yu; Yu Liu; Zhongwen Lan; Tianlong Wen; Ke Sun

doi:10.1016/j.colsurfb.2024.113754

Recent advances in functionalized ferrite nanoparticles: From fundamentals to magnetic hyperthermia cancer therapy

Colloids Surf B Biointerfaces. 2024 Feb:234:113754. doi: 10.1016/j.colsurfb.2024.113754. Epub 2024 Jan 14.

Authors

Linxue Zhang¹, Qifan Li¹, Junxiao Liu², Zunyi Deng³, Xueliang Zhang⁴, Nuernisha Alifu⁵, Xiaofeng Zhang¹, Zhong Yu¹, Yu Liu¹, Zhongwen Lan¹, Tianlong Wen⁶, Ke Sun⁷

Affiliations

¹ School of Materials and Energy, University of Electronic Science and Technology of China, Chengdu 610054, PR China.
² School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu 610072, PR China.
³ School of Aerospace Engineering, Beijing Institute of Technology, Beijing 100081, PR China.
⁴ School of Materials and Energy, University of Electronic Science and Technology of China, Chengdu 610054, PR China; School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu 610072, PR China; School of Aerospace Engineering, Beijing Institute of Technology, Beijing 100081, PR China; State Key Laboratory of Pathogenesis, Prevention, and Treatment of High Incidence Diseases in Central Asia/School of Medical Engineering and Technology, Xinjiang Medical University, Urumqi 830054, PR China.
⁵ State Key Laboratory of Pathogenesis, Prevention, and Treatment of High Incidence Diseases in Central Asia/School of Medical Engineering and Technology, Xinjiang Medical University, Urumqi 830054, PR China.
⁶ School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu 610072, PR China. Electronic address: halong@uestc.edu.cn.
⁷ School of Materials and Energy, University of Electronic Science and Technology of China, Chengdu 610054, PR China. Electronic address: ksun@uestc.edu.cn.

PMID: 38241891
DOI: 10.1016/j.colsurfb.2024.113754

Abstract

Cancers are fatal diseases that lead to most death of human beings, which urgently require effective treatments methods. Hyperthermia therapy employs magnetic nanoparticles (MNPs) as heating medium under external alternating magnetic field. Among various MNPs, ferrite nanoparticles (FNPs) have gained significant attention for hyperthermia therapy due to their exceptional magnetic properties, high stability, favorable biological compatibility, and low toxicity. The utilization of FNPs holds immense potential for enhancing the effectiveness of hyperthermia therapy. The main hurdle for hyperthermia treatment includes optimizing the heat generation capacity of FNPs and controlling the local temperature of tumor region. This review aims to comprehensively evaluate the magnetic hyperthermia treatment (MHT) of FNPs, which is accomplished by elucidating the underlying mechanism of heat generation and identifying influential factors. Based upon fundamental understanding of hyperthermia of FNPs, valuable insights will be provided for developing efficient nanoplatforms with enhanced accuracy and magnetothermal properties. Additionally, we will also survey current research focuses on modulating FNPs' properties, external conditions for MHT, novel technical methods, and recent clinical findings. Finally, current challenges in MHT with FNPs will be discussed while prospecting future directions.

Keywords: Ferrite nanoparticles; Heat generation; Magnetic hyperthermia treatment; Therapeutic efficacy; Tumor therapy.

Publication types

Review

MeSH terms

Ferric Compounds*
Humans
Hyperthermia, Induced* / methods
Magnetic Fields
Magnetite Nanoparticles* / therapeutic use
Nanoparticles*
Neoplasms* / therapy

Substances

ferrite
Magnetite Nanoparticles
Ferric Compounds