Research progress of exosomes in drug resistance of breast cancer

Lihui Liu; Daqing Jiang; Shi Bai; Xinfeng Zhang; Yue Kang

doi:10.3389/fbioe.2023.1214648

Research progress of exosomes in drug resistance of breast cancer

Front Bioeng Biotechnol. 2024 Jan 4:11:1214648. doi: 10.3389/fbioe.2023.1214648. eCollection 2023.

Authors

Lihui Liu^{1

2}, Daqing Jiang¹, Shi Bai³, Xinfeng Zhang¹, Yue Kang¹

Affiliations

¹ Department of Breast Surgery, Liaoning Cancer Hospital and Institute, Cancer Hospital of Dalian University of Technology, Cancer Hospital of China Medical University, Shenyang, China.
² Liaoning University of Traditional Chinese Medicine, Shenyang, China.
³ School of Information Science and Engineering, Shenyang University of Technology, Shenyang, China.

Abstract

Since breast cancer is a heterogeneous disease, there are currently a variety of treatment methods available, including chemotherapy, endocrine therapy, molecular targeted therapy, immunotherapy, radiation therapy, etc. Breast cancer recurrence and metastasis, despite many treatment modalities, constitute a considerable threat to patients' survival time and pose a clinical challenge that is difficult to tackle precisely. Exosomes have a very special and crucial role in the treatment of drug resistance in breast cancer as a carrier of intercellular communication in the tumor microenvironment. Exosomes and breast cancer treatment resistance have been linked in a growing number of clinical investigations in recent years. This paper covers the status of research on exosomes in the treatment of breast cancer drug resistance and offers theoretical guidance for investigating new strategies to treat breast cancer drug resistance.

Keywords: breast cancer; drug resistance; exosomes; review; review exosomes.

Publication types

Review

Grants and funding

This study was supported by part of National Natural Science Foundation of China (Grant No. 62001313), Key Project of Liaoning Provincial Department of Science and Technology (Grant No. 2021JH2/10300134 and 2022JH1/10500004), Liaoning Provincial Natural Science Foundation of China (Grant No. 2022-YGJC-11, 2022-YGJC-29, and 2022-YGJC-35), Key project of Liaoning Provincial Department of Education (Grant No. LJKZ0133), Science and Technology Project of Shenyang City (Grant No. 22-321-32-09).