This symposium provided a forum for presentations by the relevant groups on ligand design and ligand binding on the adenosine A1, receptor. Agreement appears to exist that the "N6-C8" model of ligand binding to the receptor is the preferred mode. A consensus has not yet been reached on the actual placement of the ligand in the receptor and the exact amino acids which interact in its binding. Two viable models exist at present. Both can be tested with selective site-directed mutagenic studies on the A1 receptor as well as with additional designed ligands.
Keywords: MDL 100,991; N6–C8 model; R-PIA; adenosine; theophylline.