Decoding anaphylatoxins: unveiling the molecular mechanisms of complement receptor activation and signaling

Abstract

Recent advances in cryo-electron microscopy (Cryo-EM) have revolutionized our understanding of the complement C5a/C3a receptors that are crucial in inflammation. A recent report by Yadav et al. has elucidated the activation, ligand binding, selectivity, and signaling bias of these receptors, thereby enhancing structure-guided drug discovery. This paves the way for more effective anti-inflammatory therapies that target these receptors with unprecedented precision.

Keywords: GPCR receptors C5aR1 and C3aR; agonist binding; anaphylatoxins C5a and C3a; receptor activation; selectivity; signaling bias.