A Correlation Study to Comprehend the SAR-COV-2 Viral Load, Antiviral Antibody Titer, and Severity of COVID-19 Symptoms Post-infection Amongst the Vaccinated Population in Kamrup District of Assam, Northeast India

Aparup Patra; Asis Bala; Mojibur R Khan; Ashis K Mukherjee

doi:10.2174/0118715303281124231213110004

A Correlation Study to Comprehend the SAR-COV-2 Viral Load, Antiviral Antibody Titer, and Severity of COVID-19 Symptoms Post-infection Amongst the Vaccinated Population in Kamrup District of Assam, Northeast India

Endocr Metab Immune Disord Drug Targets. 2024 Jan 12. doi: 10.2174/0118715303281124231213110004. Online ahead of print.

Authors

Aparup Patra¹, Asis Bala¹, Mojibur R Khan¹, Ashis K Mukherjee¹

Affiliation

¹ Institute of Advanced Studies in Science and Technology, Vigyan Path Garchuk, Paschim Boragaon, Guwahati-781035, Assam, India.

PMID: 38231052
DOI: 10.2174/0118715303281124231213110004

Abstract

Background: As per the recommendation of the United States Food and Drug Administration, more research is needed to determine the antibody titer against COVID-19 vaccination.

Objective: The study aimed to understand the relationship between the antibody titer to the demographics, infection severity, and cycle threshold (CT) values of confirmed COVID-19 patients.

Methods: Initially, we obtained consent from 185 populations and included sixty RT-PCRpositive COVID-19 patients from Kamrup District in the Northeast State of Assam, India. The vaccination status was recorded and tested for the level of serum immunoglobulin (IgG). The CT values, gender, and clinical symptoms-based scoring (CSBS) correlated with their IgG value.

Results: Around 48% of participants gained an antibody titer more than the threshold value and showed CT values between 18-25. Moreover, the maximum distributed score above the average was found between the CT values 18-25.

Conclusion: The IgG titer value differs significantly amongst the vaccinated population, which may depend upon their genetic and demographic variability.

Keywords: COVID-19; IgG against SARS-CoV-2 vaccination; SARS-CoV-2; cycle threshold value..