Multi-lineage Differentiation from Hematopoietic Stem Cells

Xiaoshuang Wang; Siqi Liu; Jia Yu

doi:10.1007/978-981-99-7471-9_10

Multi-lineage Differentiation from Hematopoietic Stem Cells

Adv Exp Med Biol. 2023:1442:159-175. doi: 10.1007/978-981-99-7471-9_10.

Authors

Xiaoshuang Wang^{1

2}, Siqi Liu³, Jia Yu^{4

5}

Affiliations

¹ The State Key Laboratory for Complex, Severe, and Rare Diseases, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences / Peking Union Medical College, Beijing, China. wangxs@ibms.pumc.edu.cn.
² The Institute of Blood Transfusion, Chinese Academy of Medical Sciences / Peking Union Medical College, Chengdu, China. wangxs@ibms.pumc.edu.cn.
³ State Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences / Peking Union Medical College, Beijing, China.
⁴ State Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences / Peking Union Medical College, Beijing, China. j-yu@ibms.pumc.edu.cn.
⁵ The Institute of Blood Transfusion, Chinese Academy of Medical Sciences / Peking Union Medical College, Chengdu, China. j-yu@ibms.pumc.edu.cn.

PMID: 38228964
DOI: 10.1007/978-981-99-7471-9_10

Abstract

The hematopoietic stem cells (HSCs) have the ability to differentiate and give rise to all mature blood cells. Commitment to differentiation progressively limits the self-renewal potential of the original HSCs by regulating the level of lineage-specific gene expression. In this review, we will summarize the current understanding of the molecular mechanisms underlying HSC differentiation toward erythroid, myeloid, and lymphocyte lineages. Moreover, we will decipher how the single-cell technologies advance the lineage-biased HSC subpopulations and their differentiation potential.

Keywords: Epigenetic regulation; Hematopoietic stem cell; Lineage differentiation; Non-coding RNA; Single-cell technology; Transcription factor networks.

Publication types

Review

MeSH terms

Cell Differentiation / physiology
Cell Lineage / genetics
Hematopoietic Stem Cells*