A novel adjustable PHBV basement film for enhancing the efficacy of glaucoma surgery by inhibiting scar formation

Dengming Zhou; Wenxiang Zhu; Hairong Liu; Feng Zhang; Xiaoyu Zhou; Xinyue Zhang; Yang Zhao; Yuting Huang; Xuanchu Duan

doi:10.1016/j.mtbio.2023.100922

A novel adjustable PHBV basement film for enhancing the efficacy of glaucoma surgery by inhibiting scar formation

Mater Today Bio. 2023 Dec 22:24:100922. doi: 10.1016/j.mtbio.2023.100922. eCollection 2024 Feb.

Authors

Dengming Zhou¹, Wenxiang Zhu², Hairong Liu², Feng Zhang³, Xiaoyu Zhou¹, Xinyue Zhang¹, Yang Zhao¹, Yuting Huang⁴, Xuanchu Duan¹

Affiliations

¹ Aier Glaucoma Institute, Hunan Engineering Research Center for Glaucoma with Artificial Intelligence in Diagnosis and Application of New Materials, Changsha Aier Eye Hospital, Changsha, China, 410015.
² College of Materials Science and Engineering, Hunan University, Changsha, 410082, China.
³ The Third Xiangya Hospital, Central South University, Changsha, 410013, China.
⁴ Shanghai Achieva Medical Suzhou Co., Ltd. Suzhou, 215028, China.

Abstract

Trabeculectomy is the primary surgical approach used to treat glaucoma, but scarring of the filtering passage (filtering bleb) after surgery often leads to treatment failure. To address this issue, we have developed a drug release system called RSG/Pd@ZIF-8 PHBV film. This system enables the sustained release of an anti-fibrosis drug, aiming to prevent scarring. In vitro, the film has the function of continuous Rosiglitazone (RSG) release, with accelerated release after laser irradiation. The antibacterial experiments revealed that the film exhibited antibacterial rates of 87.0 % against E.coli and 97.1 % against S.aureus, respectively. Moreover, we confirmed its efficacy in a rabbit eye model undergoing trabeculectomy. After implantation of the film, we observed a prolonged postoperative period for reducing intraocular pressure (IOP), increased survival rate of filtering blebs, and improved long-term surgical outcomes in vivo. Additionally, the film exhibited excellent biosafety. In summary, the designed sustained-release film in this study possesses the aforementioned functionalities, allowing for the regulation of anti-scarring drug release without causing harm post-surgery. This personalized and precise anti-scarring strategy represents a significant advancement.

Keywords: Anti-scarring; Antibacterial; Glaucoma; PHBV; Trabeculectomy; ZIF-8.