Severe Ulcerative Colitis Complicated by Malakoplakia Resulting in Proctocolectomy

Lotus Alphonsus; Theshani A De Silva; David Driman; Vipul Jairath

doi:10.14309/crj.0000000000001257

Severe Ulcerative Colitis Complicated by Malakoplakia Resulting in Proctocolectomy

ACG Case Rep J. 2023 Jan 12;11(1):e01257. doi: 10.14309/crj.0000000000001257. eCollection 2024 Jan.

Authors

Lotus Alphonsus¹, Theshani A De Silva¹, David Driman², Vipul Jairath^{3

4

5}

Affiliations

¹ Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
² Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, Western University and London Health Sciences Centre, London, Ontario, Canada.
³ Division of Gastroenterology, Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
⁴ Lawson Health Research Institute, Western University, London, Ontario, Canada.
⁵ Department of Epidemiology and Biostatistics, Western University, London, Ontario, Canada.

Abstract

We report a 45-year-old man with medically refractory ulcerative colitis with superimposed colonic malakoplakia, presumed related to chronic use of azathioprine and biologics. This is the first reported case of malakoplakia in a patient requiring high doses of combination therapy. Treatment of malakoplakia is not standardized, but can involve systemic antibiotics, or surgical resection, which in this case resulted in proctocolectomy.

Keywords: malakoplakia; ulcerative colitis.

Publication types

Case Reports