Evaluating dose coverage and conformity in stereotactic ablative body radiotherapy (SABR) plans

Abstract

Purpose: Accepted conformity metrics in stereotactic ablative body radiotherapy (SABR) have significant limitations. This work aimed to develop a spatial assessment methodology that improves and automates checks of dose prescription and dose gradient from planning target volume (PTV) edge.

Methods: A Python-based script was developed to determine linear distances from the PTV edge to specified isodose, every 15 degrees on all axial slices and along the central axis in the coronal plane. A new "Internal PTV contour" distance metric is introduced as a size and shape indicator. 134 previously treated SABR patients stratified by anatomical site and PTV volume were analysed to establish baselines and tolerances for automation acceptability.

Results: In the axial plane, median distance (MD) from PTV edge to the 100 % isodose was 0.13 mm (range: -0.67 to 0.53 mm), and for the 90 % isodose was 2.37 mm (1.36 to 3.40 mm). Lung and non-Lung dose gradient criteria was established by fitting a second order polynomial to the MD as a function of "Internal PTV contour". This resulted in acceptability criteria of MD + 1 mm for 80 % isodose and MD + 2 mm for the 50 % isodose. For the coronal plane, MD to the 100 % isodose was 0.49 mm (-1.24 to 2.14 mm) and for the 90 % was 1.73 mm (-0.49 to 4.13 mm).

Conclusions: Our in-house script enables a high-quality spatial assessment of PTV dose coverage and gradient, with the new 'Internal PTV contour' distance metric correlating well with dose gradient.