Association between oral frailty and lower urinary tract symptoms among middle-aged and older adults in community-dwelling individuals: a cross-sectional study

Fumiya Yoneyama; Teppei Okamoto; Yoshihiro Tamura; Noritaka Ishii; Kyo Togashi; Osamu Soma; Naoki Fujita; Hayato Yamamoto; Shingo Hatakeyama; Wataru Kobayashi; Chikara Ohyama

doi:10.1007/s11255-023-03878-6

Association between oral frailty and lower urinary tract symptoms among middle-aged and older adults in community-dwelling individuals: a cross-sectional study

Int Urol Nephrol. 2024 Jan 12. doi: 10.1007/s11255-023-03878-6. Online ahead of print.

Authors

Affiliations

¹ Department of Urology, Hirosaki University Graduate School of Medicine, 5 Zaifu-Chou, Hirosaki, 036-8562, Japan.
² Department of Urology, Hirosaki University Graduate School of Medicine, 5 Zaifu-Chou, Hirosaki, 036-8562, Japan. t-okamoto@hirosaki-u.ac.jp.
³ Department of Oral and Maxillofacial Surgery, Hirosaki University Graduate School of Medicine, 5 Zaifu-Chou, Hirosaki, 036-8562, Japan.
⁴ Department of Advanced Transplant and Regenerative Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.

PMID: 38216828
DOI: 10.1007/s11255-023-03878-6

Abstract

Purpose: We assessed the association between oral frailty risk and LUTS among middle-aged and older adults in a community-dwelling population.

Methods: This cross-sectional study was conducted among 586 subjects aged ≥ 40 years who participated in the Iwaki Health Promotion Project in Hirosaki, Japan. We used the International Prostate Symptom Score (IPSS) and the Overactive Bladder Symptom Score (OABSS) to assess LUTS. LUTS was defined as an IPSS score of 8 or higher or meeting diagnostic criteria for OAB. Oral frailty risk was defined as experiencing two or more of the following: decreased chewing ability, decreased biting force, and dry mouth sensation. Physical performance (10-m gait speed and grip strength) was used for analysis. The association between oral frailty risk and LUTS was examined using multivariate logistic regression analyses.

Results: The study included 218 men and 370 women, of whom 140 had LUTS. The mean age of this cohort was 59 years. Significant differences were observed between the LUTS and non-LUTS groups, including age, hypertension, history of CVD, depressive status, sleep disturbance, and 10 m gait speed. The prevalence of oral frailty risk was significantly higher in the LUTS group than in the non-LUTS group (26% vs. 11%, P < 0.001). Multivariate analysis revealed that age, male gender, and oral frailty risk (odds ratio: 2.67, 95% confidence interval: 1.57-4.51, P < 0.001) were independent factors for LUTS. Moreover, oral frailty risk was an independent factor in both participants aged < 65 years and participants aged ≥ 65 years.

Conclusions: Oral frailty was independently associated with LUTS.

Keywords: Aging; Lower urinary tract symptoms; Oral frailty risk.