Distinct Inflammatory Phenotypes are associated with subclinical and clinical Cardiovascular disease in People living with HIV

P McGettrick; W Tinago; J O'Brien; S Miles; L Lawler; A Garcia-Leon; N Mahon; J Lambert; G Sheehan; A Landay; C A Sabin; A G Cotter; P W G Mallon; HIV UPBEAT Study group; All Ireland Infectious Diseases Cohort Study

doi:10.1093/infdis/jiae007

Distinct Inflammatory Phenotypes are associated with subclinical and clinical Cardiovascular disease in People living with HIV

J Infect Dis. 2024 Jan 12:jiae007. doi: 10.1093/infdis/jiae007. Online ahead of print.

Authors

P McGettrick^{1

2}, W Tinago¹, J O'Brien³, S Miles¹, L Lawler⁴, A Garcia-Leon¹, N Mahon⁵, J Lambert², G Sheehan², A Landay⁶, C A Sabin⁷, A G Cotter², P W G Mallon^{1

8}; HIV UPBEAT Study group; All Ireland Infectious Diseases Cohort Study

Collaborators

Affiliations

¹ Centre for Experimental Pathogen Host Research, University College Dublin, Ireland.
² Department of Infectious Diseases, Mater Misericordiae University Hospital, Dublin, Ireland.
³ Department of Radiology, University Hospital Limerick, Ireland.
⁴ Department of Radiology, Mater Misericordiae University Hospital, Dublin, Ireland.
⁵ Department of Cardiology, Mater Misericordiae University Hospital, Dublin, Ireland.
⁶ Department of Internal Medicine, Rush University Medical Center, Chicago, United States of America.
⁷ Institute for Global Health, University College London, London, United Kingdom.
⁸ Department of Infectious Diseases, St. Vincent's University Hospital, Dublin, Ireland.

PMID: 38214571
DOI: 10.1093/infdis/jiae007

Abstract

Despite inflammation being implicated in cardiovascular disease (CVD) in people with HIV (PWH), considerable heterogeneity within populations of PWH exists. Stratifying CVD risk based on inflammatory phenotype could play an important role. Using principal component analyses and unsupervised hierarchical clustering, we examined 38 biomarkers to identify inflammatory phenotypes in two independent cohorts of PWH. We identified three distinct inflammatory clusters present in both cohorts that associated with altered risk of both subclinical CVD (cohort 1) and prevalent clinical CVD (cohort 2) after adjusting for CVD risk factors. These data support precision medicine approaches to enhance CVD risk assessment in PWH.

Keywords: Bioprofiles; CVD; HIV; Inflammation; Subclinical CAD; phenotypes.