Somatic Versus Germline: A Case Series of Three Children With ATM-Mutated Medulloblastoma

JCO Precis Oncol. 2024 Jan:8:e2300333. doi: 10.1200/PO.23.00333.

Lydia T Tam¹, Bonnie Cole^{2

3}, Shannon M Stasi^{3

4}, Vera A Paulson⁵, Jason N Wright⁶, Corrine Hoeppner⁴, Susan Holtzclaw⁴, Erin E Crotty^{4

7

8}, Richard G Ellenbogen⁹, Amy Lee⁹, Ralph P Ermoian¹⁰, Christina M Lockwood⁵, Sarah E S Leary^{4

7

8}, Rebecca Ronsley^{4

7

8}

¹ Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA.
² Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA.
³ Department of Laboratories, Seattle Children's Hospital, Seattle, WA.
⁴ Division of Hematology, Oncology, Bone Marrow Transplant & Cellular Therapy, Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA.
⁵ Genetics Division, Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA.
⁶ Department of Radiology, Seattle Children's Hospital, University of Washington, Seattle, WA.
⁷ Department of Neurological Surgery, Seattle Children's Hospital, University of Washington, Seattle, WA.
⁸ Department of Radiation Oncology, University of Washington, Seattle, WA.
⁹ Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA.
¹⁰ Fred Hutchinson Cancer Research Center, Seattle, WA.

Abstract

Somatic versus Germline-A Case Series of Three Children with ATM- mutated Medulloblastoma.