Clinical features, socioeconomic status, management, short and long-term outcomes of patients with acute myocardial infarction: Phase I results of PEACE MENA registry

PLoS One. 2024 Jan 11;19(1):e0296056. doi: 10.1371/journal.pone.0296056. eCollection 2024.

Abstract

Background: The Program for the Evaluation and Management of Cardiac Events in the Middle East and North Africa (PEACE MENA) is a prospective registry program in Arabian countries that involves in patients with acute myocardial infarction (AMI) or acute heart failure (AHF).

Methods: This prospective, multi-center, multi-country study is the first report of the baseline characteristics and outcomes of inpatients with AMI who were enrolled during the first 14-month recruitment phase. We report the clinical characteristics, socioeconomic, educational levels, and management, in-hospital, one month and one-year outcomes.

Results: Between April 2019 and June 2020, 1377 patients with AMI were enrolled (79.1% males) from 16 Arabian countries. The mean age (± SD) was 58 ± 12 years. Almost half of the population had a net income < $500/month, and 40% had limited education. Nearly half of the cohort had a history of diabetes mellitus, hypertension, or hypercholesterolemia; 53% had STEMI, and almost half (49.7%) underwent a primary percutaneous intervention (PCI) (lowest 4.5% and highest 100%). Thrombolytics were used by 36.2%. (Lowest 6.45% and highest (90.9%). No reperfusion occurred in 13.8% of patients (lowest was 0% and highest 72.7%).Primary PCI was performed less frequently in the lower income group vs. high income group (26.3% vs. 54.7%; P<0.001). Recurrent ischemia occurred more frequently in the low-income group (10.9% vs. 7%; P = 0.018). Re-admission occurred in 9% at 1 month and 30% at 1 year, whereas 1-month mortality was 0.7% and 1-year mortality 4.7%.

Conclusion: In the MENA region, patients with AMI present at a young age and have a high burden of cardiac risk factors. Most of the patients in the registry have a low income and low educational status. There is heterogeneity among key performance indicators of AMI management among various Arabian countries.

Publication types

  • Multicenter Study

MeSH terms

  • Aged
  • Female
  • Humans
  • Male
  • Middle Aged
  • Myocardial Infarction* / epidemiology
  • Myocardial Infarction* / therapy
  • Percutaneous Coronary Intervention*
  • Prospective Studies
  • Registries
  • Social Class
  • Treatment Outcome

Grants and funding

KS, MS, SB, SD, AH, HG, AM, FA, MA, MY, HF, NF, WA, MA, PP, MA, IG, DD, AC, HA, MJ, HA, NA, MA, HA - 30 $ paid for each submitted online CRF for data collection - This work was supported by Roche Diagnostic Middle East FZCO (https://www.roche-middleeast.com/) via a grant to KH based on the milestones action plan and was paid to data collectors for their online-submitted CRF. - The funder had no role in the study design, data collection, or analysis.