The effect of lipid metabolism on age-associated cognitive decline: Lessons learned from model organisms and human

Shihao Wu; Xiaoli Liu; Haiyan Yang; Wenlin Ma; Zhao Qin

doi:10.1016/j.ibneur.2023.08.2194

The effect of lipid metabolism on age-associated cognitive decline: Lessons learned from model organisms and human

IBRO Neurosci Rep. 2023 Sep 4:15:165-169. doi: 10.1016/j.ibneur.2023.08.2194. eCollection 2023 Dec.

Authors

Shihao Wu^{1

2}, Xiaoli Liu³, Haiyan Yang^{1

4}, Wenlin Ma^{2

5}, Zhao Qin^{1

4}

Affiliations

¹ Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Orthopedic Department of Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China.
² Department of Geriatric Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China.
³ Punan Branch of Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200125, China.
⁴ Collaborative Innovation Center for Brain Science, Tongji University, Shanghai 200092, China.
⁵ Shanghai Clinical Research Center for Aging and Medicine, Shanghai 200040, China.

Abstract

Lipids are required as integral building blocks of cells to support cellular structures and functions. The intricate mechanisms underpinning lipid homeostasis are essential for the health and maintenance of the central nervous system. Here we summarize the recent advances in dissecting the effect of lipid metabolism on cognitive function and its age-associated decline by reviewing relevant studies ranging from invertebrate model organisms to mammals including human.

Keywords: Age-associated cognitive decline; Human; Lipid metabolism; Model organisms.