Chemotherapy in Pregnancy: Assessing the Safety of Adriamycin Administration in Pregnancy Complicated by Breast Cancer

Priyanshu Nain; Lakshya Seth; Ashley Shawn Bell; Priyanka Raval; Gyanendra Sharma; Monique Bethel; Garima Sharma; Avirup Guha

doi:10.1016/j.jaccas.2023.102141

Chemotherapy in Pregnancy: Assessing the Safety of Adriamycin Administration in Pregnancy Complicated by Breast Cancer

JACC Case Rep. 2023 Nov 12:28:102141. doi: 10.1016/j.jaccas.2023.102141. eCollection 2023 Dec 20.

Authors

Priyanshu Nain¹, Lakshya Seth², Ashley Shawn Bell¹, Priyanka Raval³, Gyanendra Sharma⁴, Monique Bethel⁴, Garima Sharma⁵, Avirup Guha^{1

4}

Affiliations

¹ Cardio-Oncology Program, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.
² Medical College of Georgia at Augusta University, Augusta, Georgia, USA.
³ Division of Hematology and Oncology, Department of Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.
⁴ Division of Cardiology, Department of Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.
⁵ Inova Schar Heart and Vascular, Inova Fairfax Medical Campus, Falls Church, Virginia, USA.

Abstract

Pregnancy-associated breast cancer is challenging to treat. Treatment with chemotherapeutic agents such as anthracyclines poses a risk of cardiotoxicity, despite being considered safe after the second trimester of pregnancy. Management requires multidisciplinary comanagement with cardio-obstetrics, cardiology-oncology, maternal-fetal medicine, and oncology.

Keywords: cancer; cardiomyopathy; pregnancy.

Publication types

Case Reports