Re-Thinking Hyperkalaemia Management in Chronic Kidney Disease-Beyond Food Tables and Nutrition Myths: An Evidence-Based Practice Review

Nutrients. 2023 Dec 19;16(1):3. doi: 10.3390/nu16010003.

Abstract

Potassium dysregulation can be life-threatening. Dietary potassium modification is a management strategy for hyperkalaemia. However, a 2017 review for clinical guidelines found no trials evaluating dietary restriction for managing hyperkalaemia in chronic kidney disease (CKD). Evidence regarding dietary hyperkalaemia management was reviewed and practice recommendations disseminated. A literature search using terms for potassium, hyperkalaemia, and CKD was undertaken from 2018 to October 2022. Researchers extracted data, discussed findings, and formulated practice recommendations. A consumer resource, a clinician education webinar, and workplace education sessions were developed. Eighteen studies were included. Observational studies found no association between dietary and serum potassium in CKD populations. In two studies, 40-60 mmol increases in dietary/supplemental potassium increased serum potassium by 0.2-0.4 mmol/L. No studies examined lowering dietary potassium as a therapeutic treatment for hyperkalaemia. Healthy dietary patterns were associated with improved outcomes and may predict lower serum potassium, as dietary co-factors may support potassium shifts intracellularly, and increase excretion through the bowel. The resource recommended limiting potassium additives, large servings of meat and milk, and including high-fibre foods: wholegrains, fruits, and vegetables. In seven months, the resource received > 3300 views and the webinar > 290 views. This review highlights the need for prompt review of consumer resources, hospital diets, and health professionals' knowledge.

Keywords: chronic kidney disease; dietary potassium restriction; hyperkalaemia; potassium; potassium additives.

Publication types

  • Review

MeSH terms

  • Evidence-Based Practice
  • Fruit
  • Hyperkalemia* / etiology
  • Hyperkalemia* / therapy
  • Potassium
  • Potassium, Dietary
  • Renal Insufficiency, Chronic* / therapy

Substances

  • Potassium, Dietary
  • Potassium

Grants and funding

This research received no external funding. The authors acknowledge the in-kind support provided by the Nutrition Research Collaborative, and Dietetics and Food Services Department, Royal Brisbane and Womens’ Hospital, Australia.