Comparison of tracer kinetic models for 68Ga-PSMA-11 PET in intermediate-risk primary prostate cancer patients

Nathaniel J Smith; Mark A Green; Clinton D Bahler; Mark Tann; Wendy Territo; Anne M Smith; Gary D Hutchins

doi:10.1186/s13550-023-01066-2

Comparison of tracer kinetic models for ⁶⁸Ga-PSMA-11 PET in intermediate-risk primary prostate cancer patients

EJNMMI Res. 2024 Jan 10;14(1):6. doi: 10.1186/s13550-023-01066-2.

Authors

Nathaniel J Smith^{1

2}, Mark A Green³, Clinton D Bahler³, Mark Tann³, Wendy Territo³, Anne M Smith⁴, Gary D Hutchins³

Affiliations

¹ Indiana University School of Medicine, 950 West Walnut Street, Indianapolis, IN, 46202, USA. smithnaj@iu.edu.
² Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA. smithnaj@iu.edu.
³ Indiana University School of Medicine, 950 West Walnut Street, Indianapolis, IN, 46202, USA.
⁴ Siemens Medical Solutions USA, Inc., Knoxville, TN, USA.

Abstract

Background: ⁶⁸Ga-PSMA-11 positron emission tomography enables the detection of primary, recurrent, and metastatic prostate cancer. Regional radiopharmaceutical uptake is generally evaluated in static images and quantified as standard uptake values (SUVs) for clinical decision-making. However, analysis of dynamic images characterizing both tracer uptake and pharmacokinetics may offer added insights into the underlying tissue pathophysiology. This study was undertaken to evaluate the suitability of various kinetic models for ⁶⁸Ga-PSMA-11 PET analysis. Twenty-three lesions in 18 patients were included in a retrospective kinetic evaluation of 55-min dynamic ⁶⁸Ga-PSMA-11 pre-prostatectomy PET scans from patients with biopsy-demonstrated intermediate- to high-risk prostate cancer. Three kinetic models-a reversible one-tissue compartment model, an irreversible two-tissue compartment model, and a reversible two-tissue compartment model, were evaluated for their goodness of fit to lesion and normal reference prostate time-activity curves. Kinetic parameters obtained through graphical analysis and tracer kinetic modeling techniques were compared for reference prostate tissue and lesion regions of interest.

Results: Supported by goodness of fit and information loss criteria, the irreversible two-tissue compartment model optimally fit the time-activity curves. Lesions exhibited significant differences in kinetic rate constants (K₁, k₂, k₃, K_i) and semiquantitative measures (SUV and %ID/kg) when compared with reference prostatic tissue. The two-tissue irreversible tracer kinetic model was consistently appropriate across prostatic zones.

Conclusions: An irreversible tracer kinetic model is appropriate for dynamic analysis of ⁶⁸Ga-PSMA-11 PET images. Kinetic parameters estimated by Patlak graphical analysis or full compartmental analysis can distinguish tumor from normal prostate tissue.

Keywords: 68Ga-PSMA-11 PET; Compartmental model; Dynamic imaging; Graphical model; Patlak analysis; Primary prostate cancer; Tracer kinetic model.

Abstract

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