Immune evasion by dormant disseminated cancer cells: A Fermi paradox?

Cancer Cell. 2024 Jan 8;42(1):13-15. doi: 10.1016/j.ccell.2023.12.017.

Abstract

Rare disseminated tumor cells (DTCs) can persist after treatment in patients for years, and the immune system does not eliminate them. Goddard et al. propose that immune evasion by rare dormant DTCs is due to an improbability of contact imposed by large distances separating effector T cells and DTCs.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Humans
  • Immune Evasion*
  • Neoplasms*