Successful topical minoxidil treatment for hair density and length in trichorhinophalangeal syndrome type 1

Mira Choi; Allison Han; Lawrence F Eichenfield

doi:10.1111/pde.15509

Successful topical minoxidil treatment for hair density and length in trichorhinophalangeal syndrome type 1

Pediatr Dermatol. 2024 Mar-Apr;41(2):366-368. doi: 10.1111/pde.15509. Epub 2024 Jan 9.

Authors

Mira Choi^{1

2}, Allison Han¹, Lawrence F Eichenfield^{1

3

4}

Affiliations

¹ Division of Pediatric and Adolescent Dermatology, Rady Children's Hospital, San Diego, California, USA.
² Department of Dermatology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.
³ Department of Dermatology, University of California San Diego School of Medicine, San Diego, California, USA.
⁴ Department of Pediatrics, University of California San Diego School of Medicine, San Diego, California, USA.

PMID: 38193387
DOI: 10.1111/pde.15509

Abstract

A 9-year-old girl presented with slow hair growth and hair thinning since birth. Additionally, she had short stature and abnormally short fingers; genetic testing confirmed the diagnosis of trichorhinophalangeal syndrome (TRPS) type 1. After 4 months of topical minoxidil treatment, hair density and length significantly improved diffusely throughout the scalp without evidence of hypertrichosis. This case underscores the therapeutic potential of topical minoxidil for TRPS, paving the way for improved patient quality of life.

Keywords: alopecia; genetic disease; therapeutics.

Publication types

Case Reports
Letter

MeSH terms

Administration, Topical
Alopecia / drug therapy
Child
Female
Fingers / abnormalities*
Hair
Hair Diseases*
Humans
Langer-Giedion Syndrome*
Minoxidil* / therapeutic use
Nose / abnormalities*
Quality of Life*
Treatment Outcome

Substances

Minoxidil

Supplementary concepts

Trichorhinophalangeal Syndrome, Type I