Commentary: PFKFB3 overexpression in monocytes of patients with colon but not rectal cancer programs pro-tumor macrophages and is indicative for higher risk of tumor relapse

Nikolay Shakhpazyan; Liudmila Mikhaleva; Arcady Bedzhanyan; Nikolay Sadykhov; Konstantin Midiber; Alexander Orekhov

doi:10.3389/fimmu.2023.1290459

Commentary: PFKFB3 overexpression in monocytes of patients with colon but not rectal cancer programs pro-tumor macrophages and is indicative for higher risk of tumor relapse

Front Immunol. 2023 Dec 20:14:1290459. doi: 10.3389/fimmu.2023.1290459. eCollection 2023.

Authors

Nikolay Shakhpazyan¹, Liudmila Mikhaleva¹, Arcady Bedzhanyan², Nikolay Sadykhov¹, Konstantin Midiber^{1

3}, Alexander Orekhov^{1

4

5}

Affiliations

¹ Avtsyn Research Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow, Russia.
² Department of Abdominal Surgery and Oncology II (Coloproctology and Uro-Gynecology), Petrovsky National Research Center of Surgery, Moscow, Russia.
³ Institute of Medicine, Peoples' Friendship University of Russia named after Patrice Lumumba, Moscow, Russia.
⁴ Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Moscow, Russia.
⁵ Institute for Atherosclerosis Research, Moscow, Russia.

No abstract available

Keywords: colorectal cancer; cytokines; inflammation; metabolism; monocytes.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Colon
Humans
Leukemia, Myeloid, Acute*
Macrophages
Monocytes
Neoplasm Recurrence, Local
Phosphofructokinase-2
Rectal Neoplasms*

Substances

PFKFB3 protein, human
Phosphofructokinase-2

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This research was funded by Russian Science Foundation, Grant number 23-25-00196.