A Novel Inflammatory-Nutritional Prognostic Scoring System for Patients with Diffuse Large B Cell Lymphoma

Zanzan Wang; Yurong Bao; Zhijuan Xu; Yongcheng Sun; Xiao Yan; Lixia Sheng; Guifang Ouyang

doi:10.2147/JIR.S436392

A Novel Inflammatory-Nutritional Prognostic Scoring System for Patients with Diffuse Large B Cell Lymphoma

J Inflamm Res. 2024 Jan 3:17:1-13. doi: 10.2147/JIR.S436392. eCollection 2024.

Authors

Zanzan Wang^#¹, Yurong Bao^#¹, Zhijuan Xu¹, Yongcheng Sun¹, Xiao Yan¹, Lixia Sheng¹, Guifang Ouyang¹

Affiliation

¹ Department of Hematology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, People's Republic of China.

^# Contributed equally.

Abstract

Purpose: This study aimed to examine the predictive ability of inflammatory and nutritional markers and further establish a novel inflammatory nutritional prognostic scoring (INPS) system.

Patients and methods: We collected clinicopathological and baseline laboratory data of 352 patients with DLBCL between April 2010 and January 2023 at the First affiliated hospital of Ningbo University. Eligible patients were randomly divided into training and validation cohorts (n = 281 and 71, respectively) in an 8:2 ratio. We used the least absolute shrinkage and selection operator (LASSO) Cox regression model to determine the most important factors among the eight inflammatory-nutritional variables. The impact of INPS on OS was evaluated using the Kaplan-Meier curve and the Log rank test. A prognostic nomogram was developed based on the multivariate Cox regression method. Then, we used the concordance index (C-index), calibration plot, and time-dependent receiver operating characteristic (ROC) analysis to evaluate the prognostic performance and predictive accuracy of the nomogram.

Results: Seven inflammatory-nutritional biomarkers, including neutrophil-lymphocyte ratio (NLR), prognostic nutritional index (PNI), body mass index (BMI), monocyte-lymphocyte ratio (MLR), prealbumin, C reactive protein, and D-dimer were selected using the LASSO Cox analysis to construct INPS, In the multivariate analysis, IPI-High-intermediate group, IPI-High group, high INPS were independently associated with OS, respectively. The prognostic nomogram for overall survival consisting of the above two indicators showed excellent discrimination. The C-index for the nomogram was 0.94 and 0.95 in the training and validation cohorts. The time-dependent ROC curves showed that the predictive accuracy of the nomogram for OS was better than that of the NCCN-IPI system.

Conclusion: The INPS based on seven inflammatory-nutritional indexes was a reliable and convenient predictor of outcomes in DLBCL patients.

Keywords: LASSO Cox analysis; diffuse large B cell lymphoma; inflammatory-nutritional biomarker; overall survival; prognostic nomograms.

Grants and funding

This work was supported by grants from the Medical and Health Science and Technology Project of Zhejiang Province (Grant No. 2023KY316, Grant No. 2021KY273) and the Technological Project of Ningbo City (Grant No. 2022S032).