Assessment of unilateral condylar hyperplasia with quantitative SPECT/CT

Pingan Liu; Jun Shi

doi:10.1016/j.heliyon.2023.e23777

Assessment of unilateral condylar hyperplasia with quantitative SPECT/CT

Heliyon. 2023 Dec 15;10(1):e23777. doi: 10.1016/j.heliyon.2023.e23777. eCollection 2024 Jan 15.

Authors

Pingan Liu¹, Jun Shi²

Affiliations

¹ Department ofNuclear Medicine, China.
² Department of Oral and Craniomaxillofacial Science, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Abstract

Purpose: The current study aimedto assess condylar activityin patients with unilateral condylar hyperplasia (UCH) with quantitative SPECT/CT.

Patients and methods: This retrospective study included patients with UCH who underwent quantitative SPECT/CT. SPECT analysis and quantification of SPECT/CT were performed, and the maximum count per pixel and SUVmax of either side of the condyles were calculated.

Results: 39 patients were included in the analysisand classified into three subgroups according to the percentile differential right-left ratio: inactive group, left active (LA) group, and right active (RA) group. Totally, the SUVmax of the affected side is significantly higher than the unaffected side (active:5.93 ± 2.43 vs inactive:3.62 ± 1.76, P < 0.001), SUVmax-based ratios correlated well with the ratios based on maximum count (R = 0.944, P < 0.001). ROC analysis showed poorSUVmaxperformance in differentiation between theactive condyles and the inactive condyles due to the lower area under the curve (AUC) (0.588). In subgroup analysis, the affected side is significantly higher than the unaffected side in active groups with SUVmax, no significant difference was found between the active sides or the inactive sides of active groups. Interestingly, the SUVmax of the left side was statistically higher than that of the right sidein the inactive group (P = 0.01),while the left side of the right active group has significantlylower activitythan that in the inactive group, meanwhile,the right side showed no significant difference. Furthermore, each side showed no significant difference between the left active group and the inactive group.

Conclusions: SUVmax is not an optimal measurement effectively used to evaluate active condyles. However, SUV ratios correlated well with the count ratios, and the left side of condyles showed a peculiar feature in condyle growth status reflected in radioactivity quantified with SPECT/CT, which needs further study to determine the role in the development of the UCH.

Keywords: 99mTc-Methylene diphosphonate(99mTc-MDP); Quantitative SPECT/CT; Standardized uptake value(SUV); Unilateral condylar hyperplasia (UCH).