CAPG is a novel biomarker for early gastric cancer and is involved in the Wnt/β-catenin signaling pathway

Yan Long; JiaQi Wu; Yu Shen; Chenxiao Gan; Chuandong Zhang; Gang Wang; Jiyong Jing; Chenjing Zhang; Wensheng Pan

doi:10.1038/s41420-023-01767-6

CAPG is a novel biomarker for early gastric cancer and is involved in the Wnt/β-catenin signaling pathway

Cell Death Discov. 2024 Jan 8;10(1):15. doi: 10.1038/s41420-023-01767-6.

Authors

Yan Long^#¹, JiaQi Wu^#², Yu Shen³, Chenxiao Gan³, Chuandong Zhang⁴, Gang Wang⁵, Jiyong Jing⁶, Chenjing Zhang⁷, Wensheng Pan⁸

Affiliations

¹ Cancer Center, Department of Gastroenterology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, No. 158 Shangtang Road, Hangzhou, Zhejiang, China.
² Department of Gastroenterology, Affiliated Hospital of Hangzhou Normal University, 310015, Hangzhou, China.
³ Zhejiang Chinese Medical University, Hangzhou, China.
⁴ The Medical College of QingDao University, Qingdao, Shandong, China.
⁵ Shulan International Medical College, Zhejiang Shuren University, Hangzhou, Zhejiang, China.
⁶ Department of Medical Education and Simulation Center, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, 310014, Hangzhou, Zhejiang, China.
⁷ Cancer Center, Department of Gastroenterology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, No. 158 Shangtang Road, Hangzhou, Zhejiang, China. zhangcj2000@163.com.
⁸ Cancer Center, Department of Gastroenterology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, No. 158 Shangtang Road, Hangzhou, Zhejiang, China. wspan223@163.com.

^# Contributed equally.

Abstract

Past studies have shown that the Gelsolin-like actin-capping protein (CAPG) regulates cell migration and proliferation and is strongly associated with tumor progression. We present the first study of the mechanism of action of CAPG in early gastric cancer (EGC). We demonstrate that CAPG expression is upregulated in gastric cancer (GC) especially EGC. CAPG promotes GC proliferation, migration, invasion, and metastasis in vivo and in vitro. More importantly, CAPG plays a role in GC by involving the Wnt/β-catenin signaling pathway. Our findings suggest that CAPG may function as a novel biomarker for EGC.