High expression of ARPC1B correlates with immune infiltration and poor outcomes in glioblastoma

Chuangxin Liao; Wenli Chen; Guixin Xu; Jingshan Wang; Weijie Dong

doi:10.1016/j.bbrep.2023.101619

High expression of ARPC1B correlates with immune infiltration and poor outcomes in glioblastoma

Biochem Biophys Rep. 2023 Dec 19:37:101619. doi: 10.1016/j.bbrep.2023.101619. eCollection 2024 Mar.

Authors

Chuangxin Liao¹, Wenli Chen¹, Guixin Xu¹, Jingshan Wang¹, Weijie Dong¹

Affiliation

¹ Department of Neurosurgery, The Eastern Hospital of the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Abstract

Objective: To investigate the role of ARPC1B in GBM and its prognostic value.

Methods: mRNA and protein expression of ARPC1B in GBM was analyzed using the TCGA; TIMER2 and the HPA databases, and protein expression differences were detected using immunohistochemistry. K-M analysis and Cox regression analysis were performed on high and low ARPC1B expression groups in the TCGA database. The relationship between immune cells and ARPC1B expression was explored using the TIMER2 database. GO and KEGG analyses were conducted to investigate the functions of ARPC1B-related genes in GBM.

Results: ARPC1B was highly expressed in both GBM tissues and cell lines, and it was demonstrated as a prognostic biomarker for GBM. ARPC1B expression levels showed associations with immune cell populations within the GBM microenvironment.

Conclusion: ARPC1B can regulating immune infiltration in the GBM microenvironment, indicating its potential as a novel therapeutic target for GBM.

Keywords: ARPC1B; Glioblastoma; Immune infiltration; Outcome.