Macrophage-derived biomimetic nanoparticles enhanced SDT combined with immunotherapy inhibited tumor growth and metastasis

Sijie Chen; Tianliang Ma; Jiahao Wang; Shuailong Liang; Haiqin Liao; Wanlin Tan; Mingyu Chen; Xiaohui Zhou; Yan Xu; Long Wang; Chengcheng Niu

doi:10.1016/j.biomaterials.2023.122456

Macrophage-derived biomimetic nanoparticles enhanced SDT combined with immunotherapy inhibited tumor growth and metastasis

Biomaterials. 2024 Mar:305:122456. doi: 10.1016/j.biomaterials.2023.122456. Epub 2024 Jan 5.

Authors

Affiliations

¹ Department of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China; Research Center of Ultrasonography, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China; Clinical Research Center for Ultrasound Diagnosis and Treatment in Hunan Province, China.
² Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Hunan Engineering Research Center of Biomedical Metal and Ceramic Implants, Xiangya Hospital, Central South University, Changsha, China.
³ Department of Ultrasound Diagnosis, Changsha Central Hospital, Nanhua University, Changsha, Hunan 410014, China.
⁴ Department of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China; Research Center of Ultrasonography, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China; Clinical Research Center for Ultrasound Diagnosis and Treatment in Hunan Province, China. Electronic address: niuchengcheng@csu.edu.cn.

PMID: 38184961
DOI: 10.1016/j.biomaterials.2023.122456

Abstract

Combination therapy based on sonodynamic therapy (SDT) combined with immune checkpoint blockers anti-PD-L1 provides effective anti-tumor effects. We designed a combination therapy based on M1/PLGA@IR780/CAT NPs of SDT-enhanced immunity combined with immune checkpoint blockers against PD-L1, which was based on M1 macrophage membrane-encapsulated poly (lactic-co-glycolic acid) (PLGA) nanoparticles loaded with the acoustic sensitizer IR780 and catalase (CAT) to successfully realize it. SDT based on M1/PLGA@IR780/CAT NPs could induce tumor cell death by promoting dendritic cell (DC) maturation and modulating the tumor immune microenvironment. In particular, the systemic anti-tumor immune response and potent immune memory induced upon combination with anti-PD-L1 checkpoint blockade not only alleviated the progression of mammary cancer in 4T1 mice and effectively blocked distant metastasis, but also prevented tumor recurrence, providing a promising new therapeutic strategy for clinical tumor therapy.

Keywords: Immune activation; Immune checkpoint blockade; Immunogenic cell death; M1 macrophage; Sonodynamic therapy.

MeSH terms

Animals
Biomimetics
Cell Line, Tumor
Immune Checkpoint Inhibitors*
Immunotherapy
Macrophages
Mice
Nanoparticles*
Neoplasm Recurrence, Local
Tumor Microenvironment

Substances

Immune Checkpoint Inhibitors