A protocol for the stereoselective synthesis of a Star of David [2]catenane

Weitao Ye; Hai-Na Feng; Zhi-Hui Zhang; Liang Zhang

doi:10.1016/j.xpro.2023.102821

A protocol for the stereoselective synthesis of a Star of David [2]catenane

STAR Protoc. 2024 Mar 15;5(1):102821. doi: 10.1016/j.xpro.2023.102821. Epub 2024 Jan 6.

Authors

Weitao Ye¹, Hai-Na Feng¹, Zhi-Hui Zhang², Liang Zhang³

Affiliations

¹ School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, P.R. China; School Frontiers Science Center of Molecular Intelligent Synthesis, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, P.R. China.
² School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, P.R. China; School Frontiers Science Center of Molecular Intelligent Synthesis, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, P.R. China. Electronic address: zhangzhihui@chem.ecnu.edu.cn.
³ School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, P.R. China; School Frontiers Science Center of Molecular Intelligent Synthesis, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, P.R. China. Electronic address: zhangliang@chem.ecnu.edu.cn.

Abstract

Most complex prime links exhibit inherent topological chirality, yet their high stereoinduction remains a rare occurrence. Here, we present a protocol for the stereoselective synthesis of a molecular link comprising two triple entwined rings. We describe steps for constructing the precursor circular helicate, performing ring closure metathesis, and demetallation. We also outline procedures for bio-beads separation and data analysis. This protocol holds promise for applications in molecular nanotopology. For complete details on the use and execution of this protocol, please refer to Zhang et al. (2022).¹.

Keywords: Chemistry; Material sciences.

MeSH terms

Anthracenes*
Catenanes*
Data Analysis

Substances

catenane
Anthracenes
Catenanes