Durability of deep transcranial magnetic stimulation for veterans with treatment resistant depression with comorbid suicide risk and PTSD symptoms

Psychiatry Res. 2024 Feb:332:115690. doi: 10.1016/j.psychres.2023.115690. Epub 2023 Dec 23.

Abstract

Evidence supports transcranial magnetic stimulation (TMS) as an effective treatment for symptoms of depression and PTSD; however, there has been limited investigation into the durability of symptoms reduction. The Hampton Veterans Affairs Medical Center's (HVAMC) rTMS clinic used H-coil for dTMS for Veterans with treatment-resistant depression and tracked symptomology at multiple times points up to six months post-treatment. Veterans underwent 30 session of dTMS treatment using the Hesed coil (H1 coil). The PHQ-9, PCL-5, and BSS were administered to Veterans at four time points: pretreatment, post-treatment, three months after treatment, and six months after treatment. In aggregate, there were clinically significant reductions in symptoms of depression (43.47%), PTSD (44.14%) and suicidal ideation (54.02%) at the six month follow-up relative to pretreatment. Results provide evidence of the impact and durability of dTMS on symptoms of MDD, PTSD, and suicidal ideation among Veterans with treatment-resistant depression.

Keywords: Hesed coil; Major depressive disorder; Posttraumatic stress disorder; Suicidal ideation; Transcranial magnetic stimulation; Treatment resistant depression; Veterans; dTMS.

MeSH terms

  • Depressive Disorder, Treatment-Resistant* / therapy
  • Humans
  • Stress Disorders, Post-Traumatic* / complications
  • Stress Disorders, Post-Traumatic* / diagnosis
  • Stress Disorders, Post-Traumatic* / therapy
  • Suicidal Ideation
  • Transcranial Magnetic Stimulation / methods
  • Treatment Outcome
  • Veterans*