A novel designed nanofibrous mat based on hydroxypropyl methyl cellulose incorporating mango peel extract for potential use in wound care system

Abstract

Skin tissue is damaged by factors such as burns, physical injuries and diseases namely diabetes. Infection and non-healing of burn wounds and lack of angiogenesis in diabetic wounds lead to extensive injuries and death. Therefore, the design of wound dressings with antibacterial and restorative capabilities is very important. In this study, nanofibers (NFs) including polyurethane (PU) and hydroxypropyl methyl cellulose (HPMC) were prepared with different ratios and Mango peel extract (MPE) loaded into NFs by electrospinning method. The morphology, chemical structure, porosity, degradation, water vapor permeability, mechanical properties, wettability, antioxidant activity and some cell studies and evaluation of their antibacterial properties were investigated. The optimal mat (PU90/HPMC10) had a defect-free morphology with homogeneous NFs. Furthermore, it showed improved biodegradability, water vapor permeability and porosity compared to other Mats. All NFs were non-toxic with hydrophilic behavior in the cellular environment and had acceptable hemocompatibility. The PU90/HPMC10/20 % optimal scaffold had significantly higher cell viability and proliferation than other samples and also had a higher antibacterial ability against pathogenic bacteria S. aureus (17 mm) and E. coli (11 mm). All these findings confirm that the produced NF mats, especially those loaded with MPE, have a high potential to be used as an effective wound dressing.

Keywords: Hydroxypropyl methyl cellulose; Nanofibrous mat; Wound dressing.