Enhancing Angioinvasion Assessment in Papillary Thyroid Cancer via a Biomarker Panel Involving TAC, 8-OHdG and Sortilin

Angelika Buczyńska; Maria Kościuszko; Iwona Sidorkiewicz; Aleksandra Anna Wiatr; Agnieszka Adamska; Katarzyna Siewko; Janusz Dzięcioł; Małgorzata Szelachowska; Adam Jacek Krętowski; Anna Popławska-Kita

doi:10.1210/clinem/dgae007

Enhancing Angioinvasion Assessment in Papillary Thyroid Cancer via a Biomarker Panel Involving TAC, 8-OHdG and Sortilin

J Clin Endocrinol Metab. 2024 Jan 5:dgae007. doi: 10.1210/clinem/dgae007. Online ahead of print.

Affiliations

¹ Clinical Research Centre, Medical University of Bialystok, 15-276 Bialystok, Poland.
² Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, 15-276 Bialystok, Poland.
³ Clinical Research Support Centre, Medical University of Bialystok, 15-276 Bialystok, Poland.
⁴ Department of Human Anatomy, Medical University of Bialystok, 15-276 Bialystok, Poland.

PMID: 38181425
DOI: 10.1210/clinem/dgae007

Abstract

Context: Papillary thyroid cancer (PTC) aggressiveness and metastatic potential are closely associated with angioinvasion. Identifying angioinvasion accurately is imperative for treatment planning and prognosis.

Objective: This study explores serum biomarkers, including 8-hydroxydeoxyguanosine (8-OHdG) and oxidative status markers (total oxidative capacity (TOC), total antioxidant capacity (TAC), and sortilin), as potential indicators of angioinvasion in PTC.

Design: A cross-sectional study involving 50 angioinvasive PTC patients (study group) and 30 PTC patients with low-risk features (reference group). Serum levels of biomarkers were analyzed to determine their association with angioinvasion.

Setting: Patients were recruited from Department of Endocrinology, Diabetology, and Internal Diseases, Medical University of Bialystok, Poland, ensuring representation from a diverse clinical context.

Patients or other participants: Participants included PTC patients, with 50 in the study group and 30 in the reference group. Selection criteria, matching characteristics, and participant completion rates were duly recorded.

Intervention(s): Serum biomarkers were measured to evaluate their association with PTC angioinvasion.

Main outcome measure(s): Primary outcome measures included serum levels of 8-OHdG, TOC, TAC, and sortilin.

Results: Serum levels of 8-OHdG and sortilin were significantly elevated in angioinvasive PTC, while TAC showed a notable decrease (all p < 0.01). A regression panel combining TAC, 8-OHdG, and sortilin demonstrated a high AUC value (0.963) for angioinvasion discernment.

Conclusions: Measuring TAC, 8-OHdG, and sortilin levels may serve as potential biomarkers for identifying angioinvasion in PTC. The combined assessment of these biomarkers enhances angioinvasion discernment, aiding risk stratification and personalized treatment decisions. Further validation studies are required before integrating these biomarkers into routine clinical practice. The study adheres to the provided structure, providing concise and supported conclusions based on the results.

Keywords: 8-OHdG; angioinvasion; oxidative stress; papillary thyroid cancer; sortilin.